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ProteomicsCell autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS microglia contributes to neurodegeneration
The most common genetic mutation found in familial and sporadic amyotrophic lateral sclerosis (ALS), as well as fronto-temporal dementia (FTD), is a repeat expansion in the C9orf72 gene. C9orf72 is highly expressed in human myeloid cells, and although neuroinflammation and microglial pathology are w...
ORGANISM(S): Homo sapiens (Human) 
2023-03-02 | PXD032320 | Pride
Microglia and inflammation C9orf72 mutation C9orf72 interactome Lc-ms/ms 
TranscriptomicsRNA-seq of mouse astrocytes in monoculture and co-cultured with rat neurons (both inactive and active).
Neurons induce a dramatic transformation in developing astrocytes, causing them to develop a complex stellate morphology resembling their appearance in vivo. However, the transcriptional changes that accompany this transformation are not known, nor are the signalling mechanisms responsible. Similarl...
ORGANISM(S): Rattus norvegicus 
2017-05-02 | E-MTAB-5514 | biostudies-arrayexpress
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