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GenomicsEvolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment.
Temozolomide (TMZ) increases the overall survival of patients with glioblastoma (GBM), but its role in the clinical management of diffuse low-grade gliomas (LGG) is still being defined. DNA hypermethylation of the O 6 -methylguanine-DNA methyltransferase (MGMT) promoter is associated with an improve...
EGAS00001001179 | EGA
GenomicsSpatial and temporal evolution of distal 10q deletion, a prognostically unfavorable event in diffuse low-grade gliomas
Background: The disease course of patients with diffuse low-grade glioma is notoriously unpredictable. Temporal and spatially distinct samples may provide insight into the evolution of clinically relevant copy number aberrations (CNAs). The purpose of this study is to identify CNAs that are indicati...
EGAS00001000643 | EGA
GenomicsMutational analysis reveals the origin and therapy-driven evolution of recurrent glioma
Tumor recurrence is a leading cause of cancer mortality. Therapies for recurrent disease may fail, at least in part, because the genomic alterations driving the growth of recurrences are distinct from those in the initial tumor. To explore this hypothesis, we sequenced the exomes of 23 initial low-g...
EGAS00001000579 | EGA
TranscriptomicsType 1 interferons induce changes in core metabolism that are critical for immune function
Type 1 interferons (IFNs) induce complex responses that can be beneficial or deleterious, depending on context. Greater understanding of the mechanisms of action of these cytokines could allow new therapeutic approaches. We found that type 1 IFNs induced changes in cellular metabolism that were cr...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81889 | biostudies-arrayexpress
GenomicsGlioma Genomics Committee
Data Access Committee EGAC00001000153
EGAC00001000153 | EGA
Genomicsena-DATASET-VUMC-CCA-03-09-2014-18:57:30:134-11 - samples
Background: The disease course of patients with diffuse low-grade glioma is notoriously unpredictable. Temporal and spatially distinct samples may provide insight into the evolution of clinically relevant copy number aberrations (CNAs). The purpose of this study is to identify CNAs that are indicati...
EGAD00001001000 | EGA
GenomicsJ_Costello_20150303_dataset - samples
Dataset contains WES data from 3 astrocytoma patients: blood as control, primary tumor and recurrent tumor
EGAD00001001305 | EGA
GenomicsJ_Costello_20130912_dataset - samples
Description not provided
EGAD00001000714 | EGA
GenomicsThe CCA Genome Core is responsible for archiving the sequencing data generated by the Cancer Centre Amsterdam (CCA).
Data Access Committee EGAC00001000181
EGAC00001000181 | EGA
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