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MetabolomicsHypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239
Background: Elevated choline kinase alpha (ChoK) levels are observed in most solid tumors, including glioblastomas (GBM), and ChoK inhibitors have demonstrated limited efficacy in GBM models. Given that hypoxia is associated with resistance to GBM therapy, we hypothesized that tumor hypoxia c...
2024-06-18 | MTBLS6212 | MetaboLights
UnknownFollicular lymphoma-associated mutations in vacuolar ATPase ATP6V1B2 activate autophagic flux and mTOR.
Not available
S-EPMC6436860 | biostudies-literature
UnknownIntellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3.
Not available
S-EPMC4388619 | biostudies-literature
UnknownPrediction of Total Knee Replacement and Diagnosis of Osteoarthritis by Using Deep Learning on Knee Radiographs: Data from the Osteoarthritis Initiative.
Not available
S-EPMC7434649 | biostudies-literature
UnknownIntegrating Palliative and Oncology Care for Patients with Advanced Cancer: A Quality Improvement Intervention.
Not available
S-EPMC5749575 | biostudies-literature
UnknownMultiplex immunofluorescence to measure dynamic changes in tumor-infiltrating lymphocytes and PD-L1 in early-stage breast cancer.
Not available
S-EPMC7788790 | biostudies-literature
TranscriptomicsRNAi knock-down of MKL1 in human megakaryocytes derived from cord blood or cytapheresis
Characterize the genes regulated by MKL1/SRF complex in human megakaryocytes (MKs) derived from cord blood or cytapheresis : Using a knock down approach by small interference of MKL1 in MK progenitors, we observed a decrease in the percentage of cells with actin polymerization after adhesion on vari...
ORGANISM(S): Homo sapiens 
2009-09-14 | E-TABM-640 | biostudies-arrayexpress
UnknownChanges in T-cell subsets and clonal repertoire during chemoimmunotherapy with pembrolizumab and paclitaxel or capecitabine for metastatic triple-negative breast cancer.
Not available
S-EPMC8796261 | biostudies-literature
UnknownNeoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells.
Not available
S-EPMC7886909 | biostudies-literature
UnknownEnhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor.
Not available
S-EPMC8043038 | biostudies-literature
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