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UnknownBruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies.
Not available
S-EPMC5505166 | biostudies-literature
TranscriptomicsModeling Familial Cancer with iPSC Approaches
In vitro modeling of human disease has recently become feasible with the adoption of induced pluripotent stem cell (iPSC) technology. Here, we established patient-derived iPSCs from an Li-Fraumeni Syndrome (LFS) family and investigated the role of mutant p53 in the development of osteosarcoma (OS). ...
ORGANISM(S): Homo sapiens 
2015-04-10 | E-GEOD-58123 | biostudies-arrayexpress
TranscriptomicsInduction of a hemogenic program in mouse fibroblasts
Definitive hematopoiesis emerges during embryogenesis via an endothelial-to-hematopoietic transition. We attempted to induce this process in mouse fibroblasts by screening a panel of factors for hemogenic activity. We identified a combination of four transcription factors, Gata2, Gfi1b, cFos, and Et...
ORGANISM(S): Mus musculus 
2013-06-13 | E-GEOD-47497 | biostudies-arrayexpress
UnknownConcordance between influential adverse treatment outcomes and localized prostate cancer treatment decisions.
Not available
S-EPMC9404592 | biostudies-literature
GenomicsWdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network
The embryonic stem (ES) cell transcriptional and epigenetic networks are critical for the maintenance of ES cell self-renewal. However, it remains unclear whether components of these networks functionally interact and if so, what factors mediate such interactions. Here we show that WD-repeat protein...
ORGANISM(S): Mus musculus 
2011-04-08 | E-GEOD-22934 | biostudies-arrayexpress
UnknownModified full-face snorkel masks as reusable personal protective equipment for hospital personnel.
Not available
S-EPMC7806161 | biostudies-literature
UnknownEnergetics of the microsporidian polar tube invasion machinery.
Not available
S-EPMC10942582 | biostudies-literature
UnknownInsulator-to-Metal Transition and Isotropic Gigantic Magnetoresistance in Layered Magnetic Semiconductors.
Not available
S-EPMC11602683 | biostudies-literature
UnknownTemporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis.
Not available
S-EPMC3679525 | biostudies-literature
TranscriptomicsWdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network (2)
The embryonic stem (ES) cell transcriptional and epigenetic networks are critical for the maintenance of ES cell self-renewal. It remains unclear whether interactions. Here we show that a core member of the Set/MLL complex, WDrepeat protein-5 (Wdr5), is a novel regulator of self-renewal and partners...
ORGANISM(S): Mus musculus 
2011-04-08 | E-GEOD-19588 | biostudies-arrayexpress
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