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TranscriptomicsUridylation by TUT4 and TUT7 marks mRNA for degradation [TAIL-Seq]
Uridylation occurs pervasively on mRNAs in mammals, yet its mechanism and significance remain unknown. Here we identify TUT4 and TUT7 (also known as ZCCHC11 and ZCCHC6, respectively) as the enzymes that uridylate mRNAs. Uridylation readily occurs on deadenylated mRNAs that are not associated with po...
ORGANISM(S): Homo sapiens 
2014-12-04 | E-GEOD-59627 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide identification of LIN28A targets in mouse embryonic stem cell (A3-1) [Illumina Seq]
LIN28A is a highly-conserved RNA-binding protein which is known to be involved in embryonic development, stem cell maintenance and proliferation. LIN28A is expressed in various types of cancer, and they are associated with advanced tumor malignancy. In embryonic stem cell, LIN28A specifically binds ...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-37111 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling for changes upon Lin28a knockdown in mouse embryonic stem cell (A3-1) [Affymetrix]
LIN28A is a highly-conserved RNA-binding protein which is known to be involved in embryonic development, stem cell maintenance and proliferation. LIN28A is expressed in various types of cancer, and they are associated with advanced tumor malignancy. In embryonic stem cell, LIN28A specifically binds ...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-37113 | biostudies-arrayexpress
TranscriptomicsLIN28A-mediated regulation of microRNA biogenesis in mouse embryonic stem cell (A3-1) [Agilent]
LIN28A is a highly-conserved RNA-binding protein which is known to be involved in embryonic development, stem cell maintenance and proliferation. LIN28A is expressed in various types of cancer, and they are associated with advanced tumor malignancy. In embryonic stem cell, LIN28A specifically binds ...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-37112 | biostudies-arrayexpress
TranscriptomicsSmall RNA profiles following TUT knock-down in HeLa
The precise control of microRNA (miRNA) biogenesis is important for various cellular functions, and its dysregulation is often associated with human diseases. We previously reported that Terminal uridylyl transferase 4 (TUT4) down-regulates let-7 miRNA biogenesis by oligo-uridylating let-7 precursor...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-35835 | biostudies-arrayexpress
TranscriptomicsmRNA profiles following TUT knock-down in HeLa
The precise control of microRNA (miRNA) biogenesis is important for various cellular functions, and its dysregulation is often associated with human diseases. We previously reported that Terminal uridylyl transferase 4 (TUT4) down-regulates let-7 miRNA biogenesis by oligo-uridylating let-7 precur...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-40228 | biostudies-arrayexpress
TranscriptomicsThe effects of the 5' pocket motif of Dicer on miRNA biogenesis
A hallmark of RNA silencing is a class of ~22 nt RNAs which are processed from dsRNA precursor by Dicer. Accurate processing by Dicer is critical for the functionality of microRNAs (miRNAs). According to the current model, Dicer measures the length by anchoring the 3' overhang of the dsRNA terminus....
ORGANISM(S): Mus musculus 
2011-07-12 | E-GEOD-27903 | biostudies-arrayexpress
UnknownFunctional and molecular dissection of HCMV long non-coding RNAs.
Not available
S-EPMC9652368 | biostudies-literature
UnknownThe Architecture of SARS-CoV-2 Transcriptome.
Not available
S-EPMC7179501 | biostudies-literature
UnknownSARS-CoV-2 infection engenders heterogeneous ribonucleoprotein interactions to impede translation elongation in the lungs.
Not available
S-EPMC10767024 | biostudies-literature
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