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MetabolomicsDeletion of glycerol channel aquaporin-9 (Aqp9) impairs long-term blood glucose control in C57BL/6 leptin receptor-deficient (db/db) obese mice
Deletion of the glycerol channel aquaporin-9 (Aqp9) reduces postprandial blood glucose levels in leptin receptor deficient (db/db) obese mice on a C57BL/6×C57BLKS mixed genetic background. Furthermore, shRNA mediated reduction of Aqp9 expression reduces liver triacylglycerol (TAG) accumulation in a ...
2015-09-28 | MTBLS219 | MetaboLights
MetabolomicsTwo-Channel Chemical Isotope Labeling Metabolomics Analysis of Human Fecal Samples

Global metabolomics study of the amine and carboxyl submetabolomes of 16 human fecal samples.

2026-09-23 | MTBLS13531 | MetaboLights
MetabolomicsRibosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis

Translation fidelity is the limiting factor in the accuracy of gene expression. With an estimated frequency of 10-4, errors in mRNA decoding occur in a mostly stochastic manner. Little is known about the response of higher eukaryotes to chronic loss of ribosomal accuracy as per an increase in the...

2019-09-17 | MTBLS106 | MetaboLights
MetabolomicsATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly

The ATPase Family AAA Domain Containing 3A (ATAD3A), is a mitochondrial inner membrane protein conserved in metazoans. ATAD3A has been associated with several mitochondrial functions, including nucleoid organization, cholesterol metabolism, and mitochondrial translation. To address its primary ro...

2022-01-14 | MTBLS3786 | MetaboLights
TranscriptomicsTranscription profiling of chloride channel ClC-2 knock out mice with a Leukoencephalopathy-like phenotype vs.wild type
ClC-2 is a broadly expressed Cl- channel of the CLC family of Cl- channels and transporters which is abundantly expressed in brain. Here it was proposed to participate in lowering the cytoplasmic Cl- concentration of neurons, a process that establishes an inhibitory response to the neurotransmitters...
ORGANISM(S): Mus musculus 
2008-05-01 | E-MEXP-1028 | biostudies-arrayexpress
ProteomicsThe calcium-permeable channel OSCA1.3 regulates plant stomatal immunity
Perception of biotic and abiotic stresses often leads to stomatal closure in plants. Rapid influx of calcium ions (Ca2+) across the plasma membrane plays an important role in this response, but the identity of Ca2+ channels involved has remained elusive. Here, we report that the Arabidopsis thaliana...
ORGANISM(S): Arabidopsis Thaliana 
2020-09-11 | PXD020852 | panorama
TranscriptomicsTranscription profiling of cortical collecting duct/connecting nephron tissue from mice treated with aldosterone, canrenoate vs. controls to identify gene products regulated by aldosterone in target cells
The mineralocorticoid hormone aldosterone controls sodium reabsorption and blood pressure largely by regulating the cell-surface expression and function of the epithelial sodium channel ENaC in target kidney tubules. Part of the stimulatory effect of aldosterone on ENaC is mediated by the induct...
ORGANISM(S): Mus musculus 
2007-03-07 | E-TABM-229 | biostudies-arrayexpress
GenomicsSlo2 potassium channel function depends on a SCYL1 protein
Slo2 potassium channel function depends on a SCYL1 protein
PRJNA593043 | ENA
TranscriptomicsGene expression in mouse retinas with cone cyclic nucleotide gated channel deficiencies
The cone photoreceptor cyclic nucleotide-gated (CNG) channel is essential for central and color vision and visual acuity. Mutations in the channel subunits CNGA3 and CNGB3 are associated with achromatopsia and cone dystrophy. We investigated the gene expression profiles in mouse retina with CNG ch...
ORGANISM(S): Mus musculus 
2013-07-03 | E-GEOD-40982 | biostudies-arrayexpress
ProteomicsRegulation of the PKD2 channel function and associated disease phenotypes by RASSF4
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenic genetic disorders, caused by mutations in receptor PKD1 or ion channel PKD2, and is characterized by progressive renal cyst development with additional hepatic and extrarenal manifestations. As effective treatme...
ORGANISM(S): Homo Sapiens 
2026-02-13 | PXD074819 |
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