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GenomicsClonal Evolution of Pre-Leukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia

Acute myeloid leukemia is an aggressive clonal malignancy of the bone marrow that is the direct result of sequential acquisition of mutations in a single lineage of cells. In this study, we investigate a model in which this mutational acquisition occurs serially in long-lived self-renewing hemato...

phs000549.v1.p1 | EGA
GenomicsChIP-seq analysis of Arid1a and C/ebpα in the mouse livers
Arid1a is the subunit of SWI/SNF complex, which was reported to guide SWI/SNF to DNA. Here, we found that loss of Arid1a in the liver and other adult tissues results in improved organ regeneration. Within SWI/SNF complexes, Arid1a physically interacts with C/ebpα, a hepatocyte transcription factor ...
ORGANISM(S): Mus musculus 
2016-03-30 | E-GEOD-65167 | biostudies-arrayexpress
TranscriptomicsArabidopsis Messenger RNA N6-methyladenosine Demethylation Regulates Plant Development
N6-methyladenosine (m6A) is the most abundant internal modification in the messenger RNA (mRNA) of all higher eukaryotes. This modification has been shown to be reversible in mammals; it is installed by a methyltransferase heterodimer complex of METTL3 and METTL14 bound with WTAP, and reversed by ir...
ORGANISM(S): Arabidopsis thaliana 
2016-03-24 | E-GEOD-79523 | biostudies-arrayexpress
TranscriptomicsInhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination
We used transcription-profiling to identify mitogen-activated protein kinase (Mapk) signaling as an important regulator involved in the differentiation of oligodendrocyte progenitor cells (OPCs) into oligodendrocytes. We show in tissue culture that activation of Mapk signaling by elevation of intrac...
ORGANISM(S): Rattus norvegicus 
2013-08-29 | E-GEOD-50042 | biostudies-arrayexpress
GenomicsChIP-seq analysis of E2f4, H3K4me2 and H3K27ac in the mouse livers
Arid1a is the subunit of SWI/SNF complex, which was reported to guide SWI/SNF to DNA. Here, we found that loss of Arid1a in the liver results in improved liver regeneration after partial hepatectomy.Genome-wide analysis showed that after hepatectomy,loss of Arid1a reduces the recruitment and activi...
ORGANISM(S): Mus musculus 
2016-03-30 | E-GEOD-76927 | biostudies-arrayexpress
UnknownThe genetic architecture of the human cerebral cortex.
Not available
S-EPMC7295264 | biostudies-literature
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