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GenomicsDiscovery and Characterization of Super-Enhancer Associated Dependencies in Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma (DLBCL) is a biologically heterogeneous and clinically aggressive disease. Here, we explore the role of BET bromodomain proteins in DLBCL, using integrative chemical genetics and functional epigenomics. We observe highly asymmetric loading of BRD4 at enhancers, with app...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-46663 | biostudies-arrayexpress
GenomicsTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation [ChIP-seq]
Children with Down syndrome (DS) have a 20-fold increased risk of developing B cell acute lymphoblastic leukemia (B-ALL). Polysomy 21 (i.e., extra copies of chr.21) is also the most frequent somatic aneuploidy among all B-ALLs. Additional B-ALLs harbor intrachromosomal amplifications of chr.21q22 (i...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-48534 | biostudies-arrayexpress
TranscriptomicsIntegrative Analysis of a series of newly diagnosed Diffuse Large B-cell Lymphomas (DLBCLs)
Diffuse large B-cell lymphoma (DLBCL) is a clinically and biologically heterogeneous disease. We have characterized recurrent copy number alterations (CNAs) in a large series of primary DLBCLs with HD-SNP arrays and the GISTIC algromithm. We evaluated the associations between transcript abundance an...
ORGANISM(S): Homo sapiens 
2012-09-12 | E-GEOD-34171 | biostudies-arrayexpress
TranscriptomicsTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation [RNA-Seq]
Down syndrome (DS) confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (ALL), yet the mechanisms underlying this association are undefined.  We show that triplication of only 31 genes orthologous to the putative DS Critical Region (DSCR) on chr.21q22 is sufficient to promote B ce...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-48553 | biostudies-arrayexpress
TranscriptomicsGene Expression and HD-SNP6.0 data from Primary Testicular (PTL), Primary Central Nervous System Lymphoma (PCNSL) and Primary Mediastinal B-cell Lymphoma (PMLBCL)
We obtained gene expression data and HD-SNP6.0 copy number data from PTL, PCNSL and PMLBCL samples and performed an integrative analysis on them. RNA was whole genome amplified using Nugen. Gene expression profiles (GEP) and copy number (CN) data were obtained from 7 PTL. GEP was obtained from 15 PC...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-61578 | biostudies-arrayexpress
TranscriptomicsIntegrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
We integrate high-resolution copy number data with transcriptional profiles and identify the immunoregulatory genes, PD-L1 and PD-L2, as key targets at the 9p24.1 amplification peak in HL and MLBCL cell lines. DNA copy number alterations were defined in DLBCL and HL cell lines, normalized to healthy...
ORGANISM(S): Homo sapiens 
2010-10-06 | E-GEOD-22208 | biostudies-arrayexpress
UnknownGenomic complexity is associated with epigenetic regulator mutations and poor prognosis in diffuse large B-cell lymphoma.
Not available
S-EPMC8293967 | biostudies-literature
UnknownFBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas.
Not available
S-EPMC3344385 | biostudies-literature
UnknownPD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies.
Not available
S-EPMC4102335 | biostudies-literature
UnknownTFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions.
Not available
S-EPMC11322606 | biostudies-literature
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