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TranscriptomicsIntegrative Analysis of a series of newly diagnosed Diffuse Large B-cell Lymphomas (DLBCLs)
Diffuse large B-cell lymphoma (DLBCL) is a clinically and biologically heterogeneous disease. We have characterized recurrent copy number alterations (CNAs) in a large series of primary DLBCLs with HD-SNP arrays and the GISTIC algromithm. We evaluated the associations between transcript abundance an...
ORGANISM(S): Homo sapiens 
2012-09-12 | E-GEOD-34171 | biostudies-arrayexpress
TranscriptomicsGene Expression and HD-SNP6.0 data from Primary Testicular (PTL), Primary Central Nervous System Lymphoma (PCNSL) and Primary Mediastinal B-cell Lymphoma (PMLBCL)
We obtained gene expression data and HD-SNP6.0 copy number data from PTL, PCNSL and PMLBCL samples and performed an integrative analysis on them. RNA was whole genome amplified using Nugen. Gene expression profiles (GEP) and copy number (CN) data were obtained from 7 PTL. GEP was obtained from 15 PC...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-61578 | biostudies-arrayexpress
UnknownNivolumab in Patients With Relapsed or Refractory Hematologic Malignancy: Preliminary Results of a Phase Ib Study.
Not available
S-EPMC5019749 | biostudies-literature
TranscriptomicsType II JAK2 Inhibitor NVP-CHZ868 is Active in Vitro and in Vivo Against JAK2-Dependent B-cell Acute Lymphoblastic Leukemias
Gene expression profiling was performed to define transcriptional programs associated with response to type II JAK2 inhibitor NVP-CHZ868 alone or in combination with dexamethasone in vitro and in vivo. MHH-CALL4 cells harboring a CRLF2 rearrangement and JAK2 I682F mutation were treated with vehicle,...
ORGANISM(S): Homo sapiens 
2015-06-18 | E-GEOD-61696 | biostudies-arrayexpress
TranscriptomicsMutations in G protein beta subunits promote transformation and kinase inhibitor resistance.
Activating mutations of G protein alpha subunits (Ga) occur in 4-5% of all human cancers1 but oncogenic alterations in beta subunits (Gb) have not been defined. Here we demonstrate that recurrent mutations in the Gb proteins GNB1 and GNB2 confer cytokine-independent growth and activate canonical G ...
ORGANISM(S): Homo sapiens 
2014-12-07 | E-GEOD-60990 | biostudies-arrayexpress
TranscriptomicsTime course gene expression profiling of five diffuse large B-cell lymphoma cell lines following JQ1 treatment
To understand the molecular curcuits perturbed by BET bromodoman inhibtion we obtained gene expression profiling of five DLBCL cell lines, SU-DHL6, OCI-Ly1, OCI-Ly4, Toledo and HBL-1, which were treated with either 500nM JQ1 or DMSO for 0,2,6,12,24 and 48hr. RNA samples from five DLBCL cell lines at...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-45630 | biostudies-arrayexpress
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