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TranscriptomicsControl of Peripheral Tolerance by Regulatory T Cell-Intrinsic Notch Signaling
Notch receptors direct the differentiation of T helper (Th) cell subsets, but their influence on regulatory T (TR) cell responses is obscure. Interruption of Notch signaling in TR cells resulted in a super-regulatory phenotype, with suppression of TR cell Th1 programming and apoptosis as well as Th1...
ORGANISM(S): Mus musculus 
2015-07-25 | E-GEOD-71343 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of M0, M1 and M2a macrophages after 7 days of culture
The relative contribution of polarized macrophages to the maintenance of tolerance is unknown. We examined their roles by in vivo adoptive transfer immunotherapy of M0, M1 and M2a macrophages as pre-treatment of colitis. In other experiments, M2a macrophages were used as pre-treatment or treatment o...
ORGANISM(S): Mus musculus 
2016-03-02 | E-GEOD-72518 | biostudies-arrayexpress
TranscriptomicsPathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma
Polymorphisms in the interleukin-4 receptor ? chain (IL-4R?) have been linked to asthma incidence and severity, but a causal relationship has remained uncertain. In particular, a glutamine to arginine substitution at position 576 (Q576R) of IL-4R? has been associated with severe asthma, especially i...
ORGANISM(S): Mus musculus 
2009-10-01 | E-GEOD-18010 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of in vivo derived induced and natural FOXP3+ regulatory T cells in the mouse
The relative contribution of induced and natural Foxp3+ regulatory T cells (iTreg and nTreg cells, respectively) to the maintenance of tolerance is unknown. We examined their respective roles by in vivo adoptive transfer immunotherapy of newborn Foxp3-deficient BALB/c mice. Survival, weight gain, ...
ORGANISM(S): Mus musculus 
2011-06-30 | E-GEOD-19512 | biostudies-arrayexpress
GenomicsTreg Cell TGF-β1 Regulates Distinct Checkpoints Governing Allergy and Autoimmunity
Treg Cell TGF-β1 Regulates Distinct Checkpoints Governing Allergy and Autoimmunity
PRJNA666622 | ENA
TranscriptomicsGene expression data from IL13-induced allergic airway inflammation of mice lungs
Asthma is a common chronic inflammatory airway condition with a strong genetic and inheritability component, as siblings and first-degree relatives of those with the disease are often affected. For our studies, we used a well-characterized transgenic mouse model of allergic airway inflammation induc...
ORGANISM(S): Mus musculus 
2012-02-23 | E-GEOD-35979 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression data from IL13-induced allergic airway inflammation of mice lungs
Epigenetic changes have been implicated in pathogenesis of asthma. We sought to determine if IL13, a key cytokine in airway inflammation and remodeling, induced miRNAs expression changes in the airways in conjunction with its transcriptional gene regulation. For our studies, we used a well-character...
ORGANISM(S): Mus musculus 
2012-02-23 | E-GEOD-35980 | biostudies-arrayexpress
TranscriptomicsMethylated DNA immunoprecipitation (MeDIP) microarray data from IL13-induced allergic airway inflammation of mouse lungs
Epigenetic changes have been implicated in pathogenesis of asthma. We sought to determine if IL13, a key cytokine in airway inflammation and remodeling, induced epigenetic DNA methylation changes in the airways in conjunction with its transcriptional gene regulation. For our studies, we used a well-...
ORGANISM(S): Mus musculus 
2012-04-06 | E-GEOD-37079 | biostudies-arrayexpress
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