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UnknownCeramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes.

Objective

Aging and weight gain lead to a decline in brown and beige adipocyte functionality that exacerbates obesity and insulin resistance. We sought to determine whether sphingolipids, such as ceramides, a class of lipid metabolites that accumulate in aging and overnutrition, are sufficie...
S-EPMC7807150 | biostudies-literature
UnknownCordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis.
Ectopic ceramide accumulation in insulin-responsive tissues contributes to the development of obesity and impairs insulin sensitivity. Moreover, pharmacological inhibition of serine palmitoyl transferase (SPT), the first enzyme essential for ceramide biosynthesis using myriocin in rodents reduces bo...
S-EPMC9068713 | biostudies-literature
UnknownCeramides Increase Fatty Acid Utilization in Intestinal Progenitors to Enhance Stemness and Increase Tumor Risk.

Background & aims

Cancers of the alimentary tract, including esophageal adenocarcinomas, colorectal cancers, and cancers of the gastric cardia, are common comorbidities of obesity. Prolonged, excessive delivery of macronutrients to the cells lining the gut can increase one's risk for these c...
S-EPMC10592225 | biostudies-literature
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