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ModelsChavez2009 - a core regulatory network of OCT4 in human embryonic stem cells
Chavez2009 - a core regulatory network of OCT4 in human embryonic stem cells A core OCT4-regulated network has been identified as a test case, to analyase stem cell characteristics and cellular differentiation. This model is described in the article: ...
2005-01-01 | MODEL1305010000 | BioModels
TranscriptomicsComputational analysis of genome-wide DNA-methylation during the differentiation of human embryonic stem cells along the endodermal lineage
The generation of genome-wide data derived from methylated DNA immunoprecipitation followed by sequencing (MeDIP-Seq) has become a major tool for epigenetic studies in health and disease. The computational analysis of such data, however, still falls short on accuracy, sensitivity and speed. We propo...
ORGANISM(S): Homo sapiens 
2010-07-26 | E-GEOD-21715 | biostudies-arrayexpress
TranscriptomicsDistinct roles of Tet1 and Tet2 in mouse embryonic stem cells (RNA-Seq)
The TET proteins TET1, TET2 and TET3 constitute a new family of dioxygenases that utilize molecular oxygen and the cofactors Fe(II) and 2-oxoglutarate to convert 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and further oxidation products in DNA1-5. Here we show that Tet1 and Tet2 have d...
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-50198 | biostudies-arrayexpress
TranscriptomicsDistinct roles of Tet1 and Tet2 in mouse embryonic stem cells (CMS-Seq)
The TET proteins TET1, TET2 and TET3 constitute a new family of dioxygenases that utilize molecular oxygen and the cofactors Fe(II) and 2-oxoglutarate to convert 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and further oxidation products in DNA1-5. Here we show that Tet1 and Tet2 have d...
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-50200 | biostudies-arrayexpress
TranscriptomicsDistinct roles of Tet1 and Tet2 in mouse embryonic stem cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-50201 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of mouse intestinal adenoma identifies early steps in the formation of cancer-specific DNA methylation patterns
Aberrant CpG methylation is a universal trait of cancer cell genomes and can result in epigenetic modulation of gene activity; however, at which stages tumour-specific epigenetic patterns arise is unknown. Here, we analyse the methylome of APCM in mouse intestinal adenoma as a model of intestinal ca...
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-38983 | biostudies-arrayexpress
GenomicsModulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX
Idax/Cxxc4 is the CXXC domain protein that preferentially binds unmethylated CpG sites in vitro. By performing genome-wide mapping of Idax/Cxxc4, we report here that Idax is preferentially enriched in CpG-rich regions in genome including the promoters containing CpG islands. ChIP-seq binding site de...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-42958 | biostudies-arrayexpress
GenomicsDistinct roles of Tet1 and Tet2 in mouse embryonic stem cells [MeDIP-Seq]
The TET proteins TET1, TET2 and TET3 constitute a new family of dioxygenases that utilize molecular oxygen and the cofactors Fe(II) and 2-oxoglutarate to convert 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and further oxidation products in DNA1-5. Here we show that Tet1 and Tet2 have d...
ORGANISM(S): Mus musculus 
2014-12-03 | E-GEOD-63771 | biostudies-arrayexpress
UnknownExtensive Molecular and Clinical Heterogeneity in Patients With Histologically Diagnosed CNS-PNET Treated as a Single Entity: A Report From the Children's Oncology Group Randomized ACNS0332 Trial.
Not available
S-EPMC9153369 | biostudies-literature
GenomicsEpigenomic analysis of primary human T cells reveals novel enhancers associated with Th2 memory differentiation and asthma susceptibility (3 cell types)
A characteristic feature of asthma is the aberrant accumulation, differentiation or function of memory CD4+ T cells that produce Th2 cytokines (Th2 cells). By mapping genome-wide histone modification profiles of T cell subsets isolated from peripheral blood of healthy and asthmatic individuals, we i...
ORGANISM(S): Homo sapiens 
2014-07-05 | E-GEOD-53643 | biostudies-arrayexpress
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