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TranscriptomicsDefining precision probes which differentiate between the activity of type I and type II interferons.
To define probes which differentiate between the activity of type I or type II IFN, a human submandibular gland (HSG) cell line was cultured for 48 hours in the absence or presence of IFNa or IFNg. Gene expression was assayed at 4, 12, 24 or 48 hours and was compared to gene expression in untreated ...
ORGANISM(S): Homo sapiens 
2012-10-08 | E-GEOD-41291 | biostudies-arrayexpress
TranscriptomicsExpression data in PD-L1 positive and PD-L1 negative human melanoma samples
Blocking the PD-1/PD-L1 immunosuppressive pathway has shown promise in the treatment of certain cancers including melanoma. This study investigates differences in the gene expression profiles of human melanomas that do or do not display the immunosuppressive protein PD-L1. Further understanding of g...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-65041 | biostudies-arrayexpress
TranscriptomicsAngiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in a murine model
TGFβ inhibition attenuates chronic cigarette smoke induced lung injury and rescues lung architecture. AKR/J mice were exposed to Cigarette Smoke (CS) for a period of two months. Some animals received a treatment of Losartan (.6gr/L) orally while exposed (CS Los). These two groups are to be compare...
ORGANISM(S): Mus musculus 
2011-12-30 | E-GEOD-33561 | biostudies-arrayexpress
TranscriptomicsExpression data in human renal cell carcinoma samples from patients who did or did not respond to anti-PD-1 (Nivolumab) immunotherapy
Pre-treatment tumor expression of PD-L1 has been shown to correlate with favorable clinical outcomes following PD-1 blocking therapies. However, the majority of patients with PD-L1+ tumors do not respond to treatment. With the goal of obtaining insights into the mechanisms underlying the response to...
ORGANISM(S): Homo sapiens 
2016-08-04 | E-GEOD-67501 | biostudies-arrayexpress
TranscriptomicsAnalysis of transcription in the Drosophila melanogaster testis
Identification and annotation of all the genes in the sequenced Drosophila genome is a work in progress. Wild-type testis function requires many genes and is thus of potentially high value for the identification of transcription units. We therefore undertook a survey of the repertoire of genes expre...
ORGANISM(S): Drosophila melanogaster 
2010-06-05 | E-GEOD-462 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human ovarian cancer cells overexpressing PKA regulatory subunits
The regulatory subunit of cAMP-dependent protein kinase (PKA) exists in two isoforms, RI and RII, which distinguish the PKA isozymes, type I (PKA-I) and type II (PKA-II). Evidence obtained from a variety of different experimental approaches has shown that the relative levels of type I and type II PK...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12854 | biostudies-arrayexpress
TranscriptomicsErythroid-Specific Transcriptional Changes in PBMCs from Pulmonary Hypertension Patients
The hypothesis tested in this study was that chronic exposure of PBMCs to a hypertensive environment in remodeled pulmonary vessels would be reflected by specific transcriptional changes in these cells. The transcript profiles of PBMCs from 30 idiopathic pulmonary arterial hypertension patients (IPA...
ORGANISM(S): Homo sapiens 
2012-04-29 | E-GEOD-33463 | biostudies-arrayexpress
TranscriptomicsTh2 cytokine IL-4 is critical in initiating pulmonary vascular inflammation under hypoxic conditions and induces pulmonary vascular endothelial cell activation.
IL-4-mediated pro-inflammatory vascular responses have been implicated in the pathogenesis of chronic cardiopulmonary diseases. Our results show that hypoxia-induced collagen synthesis and early recruitment of inflammatory cells are significantly less in the lungs of IL-4 knockout (KO) mice than in ...
ORGANISM(S): Mus musculus 
2013-09-19 | E-GEOD-40999 | biostudies-arrayexpress
TranscriptomicsDifferential Gene Expression between Active and Quiescent Stages of Ulcerative Colitis: Insights into a Distinctive Pathogenesis Profile
Our objective was to elucidate patterns of gene expression underlying the progression of UC disease. Single endoscopic pinch biopsies (n=40) were assayed using the Illumina cDNA-mediated Annealing, Selection, Extension, and Ligation (DASL) microarray. Tissue was sampled in consecutive active and qui...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-GEOD-53306 | biostudies-arrayexpress
GenomicsHomo sapiens
Defining precision probes which differentiate between the activity of type I and type II interferons.
PRJNA176459 | ENA
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