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MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
MetabolomicsMetabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part III
Not available
ORGANISM(S): Homo sapiens 
ST001237 | MetabolomicsWorkbench
MetabolomicsMetabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part II
Not available
ORGANISM(S): Homo sapiens 
ST001236 | MetabolomicsWorkbench
MetabolomicsMetabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part I
Not available
ORGANISM(S): Homo sapiens 
ST001235 | MetabolomicsWorkbench
ProteomicsCAMK2D recruits RNF8-MAD2 complex to RNA splicing proteins for mitotic checkpoint activation in GBM
Glioblastoma (GBM) is a lethal brain tumor with remarkable intra-tumoral heterogeneity and therapeutic resistance which is linked to glioma stem cell (GSC). GSC contains unstable genome and elevated genomic instability could impair GSC self-renewal and tumorigenicity. In addition, GSC displays great...
ORGANISM(S): Homo Sapiens (human) 
2023-07-21 | PXD038123 | JPOST Repository
TranscriptomicsTranscription profiling of replication checkpoint response in fission yeast
Transcription profiling of replication checkpoint response in fission yeast.
ORGANISM(S): Schizosaccharomyces pombe 
2008-11-15 | E-MEXP-1902 | biostudies-arrayexpress
TranscriptomicsGenetic and transcriptome analyses of early T-cell checkpoint failure and leukemia initiation in Rag1-deficient NOD mice
Both immunodeficient and wild type NOD mice exhibit defects in control of early T-cell development in the thymus. We show that Rag1-deficient NOD mice fail to enforce both the b-selection checkpoint and an earlier T-cell commitment checkpoint, based on genome-wide genetic and transcriptome analyses....
ORGANISM(S): Mus musculus 
2013-03-07 | E-GEOD-40688 | biostudies-arrayexpress
ModelsFanconi anemia and checkpoint recovery
The FA/BRCA pathway repairs DNA interstrand crosslinks. Mutations in this pathway cause Fanconi anemia (FA), a chromosome instability syndrome with bone marrow failure and cancer predisposition. Upon DNA damage, normal and FA cells inhibit the cell cycle progression, until the G2/M checkpoint is tur...
4790 | Cell Collective
ProteomicsMapping of immunopeptidome of cancer immunotherapy with oncolytic virus and checkpoint blockade
The elucidation of therapy-induced changes to the class I major histocompatibility complex (MHC-I)-bound tumor antigens is crucial for understanding immune-mediated tumor eradication and identifying potential targets for peptide vaccines to enhance the efficacy of immunotherapies. Here, we investiga...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-06 | PXD024369 | Pride
Antitumor immunity Mhc immunoprecipitation Immune checkpoint blockade Oncolytic virus Lc-sps-ms3 Murine Fibrosarcoma Lc-ms/ms 
TranscriptomicsHypoxia-induced alterations of G2 checkpoint regulators
Hypoxia promotes an aggressive tumor phenotype with increased genomic instability, partially due to downregulation of DNA repair pathways. However, in addition to DNA repair, genome stability is also controlled by cell cycle checkpoints. An important issue is therefore whether hypoxia also can alter...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-70530 | biostudies-arrayexpress
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