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GenomicsBeta arrestin1 associated genomic regions in nicotine induced Non-Small Cell Lung Carcinoma (NSCLC) cell line A549
The multifunctional scaffolding protein M-NM-2-arrestin-1 plays a vital role in mediating the proliferative effects of nicotine through nAChR signaling. M-NM-2-arrestins were initially known as negative regulators of GPCR mediated signaling as they promote internalization and desensitization of GPCR...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-40689 | biostudies-arrayexpress
TranscriptomicsDownstream targets of ID1 transcription factor in Non-Small Cell Lung Carcinoma (NSCLC)
ID-1, known as inhibitor of differentiation or a helix loop helix transcription factor which lack the basic DNA binding domain. It is known to bind to bHLH transcription factor and inhibit those bHLH to bind to the promoter thus inhibiting further transcription. Overexpression of ID-1 has been corre...
ORGANISM(S): Homo sapiens 
2013-04-15 | E-GEOD-38944 | biostudies-arrayexpress
TranscriptomicsNicotinic acetylcholine receptors and EGF induce c-Kit ligand/Stem Cell Factor (SCF) in a M-NM-2-arrestin-1 and E2F1 dependent manner in NSCLC
Lung cancer remains the leading cause of cancer-related deaths worldwide. M-NM-2-arrestin-1 (ARRB1), a scaffolding protein involved in the termination or desensitization of signals arising from activated G-protein-coupled receptors (GPCRs) has been shown to play a role in invasion and proliferation ...
ORGANISM(S): Homo sapiens 
2013-11-10 | E-GEOD-44617 | biostudies-arrayexpress
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