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MetabolomicsMetabolome profiling by untargeted metabolomics and biomarker panel selection using machine-learning for patients in different stages of peripheral neuropathy induced by oxaliplatin

Background: Oxaliplatin-induced peripheral neuropathy (OIPN) poses a significant challenge for patients with colorectal tumor, often resulting in treatment interruption or discontinuation and subsequent treatment failure. Herein, a longitudinal untargeted metabolomic study to reveal the metabolom...

2025-08-14 | MTBLS12854 | MetaboLights
ProteomicsA human iPSC-derived sensory neuron platform for high-throughput discovery of neuroprotectants against chemotherapy-induced peripheral neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting side effect of cancer treatment, yet the lack of predictive human models has hindered therapeutic progress. We have established a scalable model of paclitaxel-induced axon degeneration and neurotoxicity in iPSC-derived sensor...
ORGANISM(S): Homo sapiens (Human) 
2026-04-03 | PXD074954 | Pride
Axon degeneration Ipsc-derived sensory neurons Ste20 kinases Neuroprotective small molecules High-throughput screening Chemotherapy-induced peripheral neuropathy 
GenomicsPsilocybin prevents chemotherapy-induced peripheral neuropathy via mitochondrial trafficking preservation
Psilocybin prevents chemotherapy-induced peripheral neuropathy via mitochondrial trafficking preservation
PRJNA1471093 | ENA
ClinicalPrevention And Treatment Of Chemotherapy-Induced Peripheral Neuropathy In Subjects With Advanced Colorectal Cancer
Prevention and treatment of the severity of symptoms of chemotherapy-induced peripheral neuropathy.
2033030 | ecrin-mdr-crc
ClinicalAcupuncture for Chemotherapy-induced Peripheral Neuropathy
In this study, a 24-week, single blinded, randomized controlled clinical trial will be conducted to examine the efficacy and safety of acupuncture for Chemotherapy Induced Peripheral Neuropathy (CIPN) in colorectal cancer patients in Hong Kong.
2277325 | ecrin-mdr-crc
ClinicalPreventive Treatment of OxaLiplatin Induced peripherAl neuRopathy in Adjuvant Colorectal Cancer
This study is to evaluate PledOx for prevention of chronic chemotherapy induced peripheral neuropathy induced by oxaliplatin in patients with Stage III or high-risk Stage II colorectal cancer (CRC).
2312035 | ecrin-mdr-crc
GenomicsFucoidan reduces NETs accumulation and alleviates chemotherapy-induced peripheral neuropathy
Fucoidan reduces NETs accumulation and alleviates chemotherapy-induced peripheral neuropathy
PRJNA1048422 | ENA
GenomicsLeukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy.
Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy.
PRJNA1333999 | ENA
ClinicalYiqi Wenjing Prescriptions Preventive Efficacy of Oxaliplatin-induced Peripheral Neuropathy Clinical Trial
This study is a randomized, placebo-controlled, double-blind, multicenter phase III clinical trial of Yiqi Wenjing prescriptions for Preventing Oxaliplatin-induced Peripheral Neuropathy.
2362427 | ecrin-mdr-crc
ClinicalPreventive Treatment of Oxaliplatin Induced Peripheral Neuropathy in Metastatic Colorectal Cancer (POLAR-M)
This study evaluates the investigational drug PledOx in the prevention of chronic chemotherapy induced peripheral neuropathy (CIPN) induced by the drug oxaliplatin.
2282877 | ecrin-mdr-crc
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