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TranscriptomicsPassage through the mammalian gut triggers a phenotypic switch required for Candida albicans commensalism
Among ~5,000,000 fungal species on Earth, Candida albicans is exceptional in its lifelong association with humans, where it exists either as a benign component of the gastrointestinal microbiome or as an invasive pathogen. Although it is generally assumed that invasiveness results from a breakdown ...
ORGANISM(S): Candida albicans 
2013-07-28 | E-GEOD-43972 | biostudies-arrayexpress
TranscriptomicsA unique iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis [ChIP_chip]
The mammalian gastrointestinal tract and the bloodstream are highly disparate biological niches, and yet certain commensal-pathogenic microorganisms are able to thrive in both environments. Here, we report the evolution of a unique transcription circuit in the yeast, Candida albicans, which determi...
ORGANISM(S): Candida albicans 
2011-07-12 | E-GEOD-30591 | biostudies-arrayexpress
TranscriptomicsOverexpression of the transcription factor GAT201 in Cryptococcus neoformans var. grubii (serotype A, H99)
Comparison of transcriptional profiles of WT Cryptococcus neoformans (H99) and strain CM126 (pRPL2b-GAT201) which overexpresses the transcription factor GAT201 using a ribosomal protein promoter Keywords: Genetic modification WT vs. CM126 competitive hybridization. 4 biological replicates including...
ORGANISM(S): Filobasidiella neoformans 
2010-05-26 | E-GEOD-10750 | biostudies-arrayexpress
TranscriptomicsStalled spliceosomes are a signal for RNAi-mediated genome defense
Using the yeast Cryptococcus neoformans, we describe a mechanism by which transposons are initially targeted for RNAi-mediated genome defense. We show that intron-containing mRNA precursors template siRNA synthesis. We identify a Spliceosome-Coupled And Nuclear RNAi (SCANR) complex required for siRN...
ORGANISM(S): Cryptococcus neoformans 
2013-01-21 | E-GEOD-43363 | biostudies-arrayexpress
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