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TranscriptomicsExpression data from 57 patients with oral cancer and 22 normal persons
In order to aid the development of patient-tailored diagnostics and therapeutics, we attempted to identify a genetic signature associated with disease prognosis in OSCC. A genome-wide analysis of transcription with the Affymetrix GeneChip Human Gene 1.0 ST Array was conducted. In this dataset, we i...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-25099 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for oral squamous cell carcinoma
In order to identify biomarkers that contribute to genetic causes of OSCC, we attempt to identify copy number variation regions (CNV) in patients with OSCC. We identified and confirmed the clinical significance of amplification regions scattered from 8q22.2 to 8q24.3. Affymetrix SNP arrays were perf...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-25103 | biostudies-arrayexpress
TranscriptomicsExpression data from GNMT knockout mice
We report that 7 of 7 female Gnmt-/- mice developed hepatocellular carcinoma (HCC), the most common form of liver cancer, at the mean age of 16.1 months. In contrast, only one-third (2/6) of male Gnmt-/- mice had HCC, the remaining had either premature death or liver necrosis. Microarray analysis sh...
ORGANISM(S): Mus musculus 
2008-12-01 | E-GEOD-9809 | biostudies-arrayexpress
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
UnknownComparing Low- or Standard-Dose Alteplase in Endovascular Thrombectomy: Insights From a Nationwide Registry.
Not available
S-EPMC10896194 | biostudies-literature
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