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MetabolomicsNPC1 regulates the distribution of phosphatidylinositol 4 kinases at Golgi and Lysosome membranes
Cholesterol and phosphoinositides (PI) are two critically important lipids that are found in cellular membranes and dysregulated in many disorders. Therefore, uncovering molecular pathways connecting these essential lipids may offer new therapeutic insights. We report that loss of function of lysoso...
2021-09-15 | MTBLS2612 | MetaboLights
MetabolomicsMetabolic adaptation of diatoms to hypersalinity

Microalgae are important primary producers and form the basis for the marine food web. As global climate changes, so do salinity levels that algae are exposed to. A metabolic response of algal cells partly alleviates the resulting osmotic stress. Some metabolites involved in the response are well...

2023-09-04 | MTBLS3177 | MetaboLights
TranscriptomicsChromatin immunoprecipitation to measure RNA polymerase II occupancy in fission yeast
The relative amount of RNA polymerase II (Pol II) associated with a given ORF provides an estimate for transcriptional efficiency. We therefore established a systematic approach to measure Pol II occupancy using chromatin immunoprecipitation followed by analysis on microarrays
ORGANISM(S): Schizosaccharomyces pombe 
2007-03-22 | E-TABM-219 | biostudies-arrayexpress
GenomicsCell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators
We report that ancestral zinc-finger-domain transcriptional regulators, previously reported to control virulence/symbiosis, implement a cell cycle (SM-bM-^FM-^RG1) transcriptional switch. To unravel how this G1-phase transcriptional program is reinstated during a primitive cell cycle, we first de...
ORGANISM(S): Sinorhizobium fredii 
2014-05-25 | E-GEOD-52849 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fission yeast wild type and yox1 mutant strains
Transcription profiling of fission yeast /yox1/ deletion and genome wide location analysis of Yox1p and Cdc10p transcription factors reveal a negative feedback interaction: /yox1 /is transcriptionally activated by MBF, and Yox1p in turn transcriptionally represses the MBF target genes (including /yo...
ORGANISM(S): Schizosaccharomyces pombe 
2009-08-20 | E-TABM-646 | biostudies-arrayexpress
UnknownMacrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state.
Not available
S-EPMC9831293 | biostudies-literature
TranscriptomicsLaSSO, a strategy for genome-wide mapping of intronic lariats and branch-points using RNA-seq
Both canonical and alternative splicing of RNAs is governed by intronic sequence elements and produces transient lariat structures fastened by branch-points within introns. To map precisely the location of branch-points on a genomic scale, we developed LaSSO (Lariat Sequence Site Origin), a data-dri...
ORGANISM(S): Schizosaccharomyces pombe 
2014-03-18 | E-GEOD-50246 | biostudies-arrayexpress
ProteomicsProteomic Profiles of Exosomes of Septic Patients Presenting to the Emergency Department Compared to Healthy Controls
Background: Septic Emergency Department (ED) patients provide a unique opportunity to investigate early sepsis. Recent work focuses on exosomes, nanoparticle-sized lipid vesicles (30-130nm) that are released into the bloodstream to transfer its contents (RNA, miRNA, DNA, protein) to other cells. Lit...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-06-29 | MSV000085646 | MassIVE
GenomicsDNA_Methylation_450K
BLUEPRINT DNA methylation profiles of monocytes, neutrophils and T cells from healthy donors
EGAD00010000850 | EGA
TranscriptomicsGene expression in Maize root region 1 at low water potential
Previous work showed that the maize primary root adapts to low water potential (-1.6 MPa) by maintaining longitudinal expansion in the apical 3 mm (region 1), whereas in the adjacent 4 mm (region 2) longitudinal expansion reaches a maximum in well-watered roots but is progressively inhibited at low ...
ORGANISM(S): Zea mays 
2010-05-26 | E-GEOD-9341 | biostudies-arrayexpress
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