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TranscriptomicsIdentification of stem cell populations in sweat glands and ducts: roles in homeostasis and wound repair
Sweat glands are abundant glands of our body and essential for thermoregulation. Like mammary glands, they originate from epidermal progenitors. However, they display few signs of cellular turnover, and whether they have stem cells and tissue regenerative capacity remain largely unexplored. Here we ...
ORGANISM(S): Mus musculus 
2013-01-02 | E-GEOD-37274 | biostudies-arrayexpress
TranscriptomicsAn RNAi screen unveils a new player in stem cell self-renewal and long-term regeneration
Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by stem cells (SCs). Following hair regeneration, SCs within the bulge and its vicinity (upper ORS which becomes the bulge for the next cycle) briefly self-renew to replenish expended SCs and ensure lon...
ORGANISM(S): Mus musculus 
2012-02-07 | E-GEOD-35575 | biostudies-arrayexpress
UnknownEngagement in Hypertension and Diabetes Clinical Trials at Federally Qualified Health Centers: A Systematic Review.
Not available
S-EPMC12000987 | biostudies-literature
TranscriptomicsKey roles for SRF in embryonic epidermal differentiation
During development, a polarized sheet of epidermal cells undergoes stratification and differentiation to produce the skin barrier. Through mechanisms poorly understood, the process involves adhesion and Notch signaling. To elucidate how epidermal embryogenesis is governed, we conditionally targeted ...
ORGANISM(S): Mus musculus 
2011-01-20 | E-GEOD-25548 | biostudies-arrayexpress
ProteomicsPrimary villous trophoblasts exposed to flame retardant BDE-47
We exposed primary villous trophoblasts to flame retardant BDE-47 (1, 5 uM) across three culture time points (15, 24, 39 hr).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-07-23 | MSV000087870 | MassIVE
ProteomicsGlobal profiling of human cyotrophoblast differentiation/invasion
We profiled purified human cytotrophoblasts derived from second trimester placenta across four culture time points (0-39 h).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-02 | MSV000086970 | MassIVE
ProteomicsRepurposing E3 ubiquitin ligases as cell surface protein degraders using Proteolysis Targeting Antibodies
The majority of current therapeutics targeting plasma membrane receptors function by antagonizing ligand binding or enzymatic activities. Typical mammalian proteins, however, consist of multiple domains executing discrete but coordinated activities, and saturating inhibition of one functional domain...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-25 | MSV000089542 | MassIVE
UnknownComparative analysis of in-silico tools in identifying pathogenic variants in dominant inherited retinal diseases.
Not available
S-EPMC11102593 | biostudies-literature
ProteomicsPharmacoproteomic characterisation of human colon and rectal cancer - CRC65 Full Proteomes
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of >10,000 proteins using mass spectrometry. Integration with prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-23 | MSV000081738 | MassIVE
UnknownBiallelic loss-of-function variants in <i>C19orf44</i> lead to retinal degeneration.
Not available
S-EPMC12358183 | biostudies-literature
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