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ProteomicsLeucine catabolic enzyme AUH regulates brown fat thermogenesis through HMGylation of PPARγ and RNA-binding function in male mice
A strong association between leucine and obesity has been well established; however, the role of leucine catabolic enzymes in adipose tissue remains largely unknown. Here, we show that knockdown of the leucine catabolic enzyme AU RNA binding methylglutaconyl-CoA hydratase (AUH) in brown adipocytes r...
ORGANISM(S): Mus Musculus 
2026-03-09 | PXD075390 |
ProteomicsDirect Evolution of Adeno-Associated Virus 5 Capsid Enables Specific Liver Tropism
Gene therapy has been thriving in recent years, as featured by general triumphs in several clinical trials to treat hemophilia. It highlights the significance of AAV mediated gene delivery to liver. AAV5 is a unique serotype with low neutralizing antibody prevalence. In this study, we generated an A...
ORGANISM(S): Adeno-associated Virus - 5 
2022-04-01 | PXD032891 |
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