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TranscriptomicsThe roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus
We investigated the roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus (DENV). Double-deficient Irf-3-/-7-/- mice infected with the DENV2 strain S221 possessed 1,000-150,000 fold higher levels of viral RNA than wild-type and single-deficient mice 24 hours after infection; how...
ORGANISM(S): Mus musculus 
2013-08-15 | E-GEOD-49871 | biostudies-arrayexpress
TranscriptomicsCancer-Associated Fibroblasts Support Lung Cancer Stemness through Paracrine IGF-II/IGF1R/Nanog Signaling
The CLS1/CAF co-culture maintained the cancer stemness. This cancer stemness was lost when the CAF feeder cells were removed during passaging. To investigate the specific signaling pathways and markers of lung CSCs, we analyzed the gene expression profile of the CLS1 sphere after CLS1/CAF co-cultur...
ORGANISM(S): Homo sapiens 
2014-03-25 | E-GEOD-38678 | biostudies-arrayexpress
ProteomicsTargeting PILRα, an immune checkpoint mediating T cell suppression, for cancer immunotherapy
One of the most successful therapies in cancer treatment involves immune checkpoint blockade using the anti-programmed death-1 (anti-PD-1)/programmed death-ligand 1 (PD-L1) antibody, which targets the interaction between tumors and T cells. However, the overall response rate is < 30% in patients wit...
ORGANISM(S): Homo Sapiens 
2024-01-25 | PXD048903 |
UnknownTreatable traits in the NOVELTY study.
Not available
S-EPMC9795904 | biostudies-literature
UnknownSymptom Burden, Health Status, and Productivity in Patients with Uncontrolled and Controlled Severe Asthma in NOVELTY.
Not available
S-EPMC10274410 | biostudies-literature
UnknownChronic Airways Assessment Test: psychometric properties in patients with asthma and/or COPD.
Not available
S-EPMC10082977 | biostudies-literature
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