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TranscriptomicsSIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing [CLIP-Seq]
SIRT7 is an NAD+-dependent protein deacetylase with important roles in ribosome biogenesis and cell proliferation. Previous studies have established that SIRT7 is associated with RNA polymerase I, interacts with pre-rRNA and promotes rRNA synthesis. Here we show that SIRT7 is also associated with sn...
ORGANISM(S): Homo sapiens 
2016-01-07 | E-GEOD-76578 | biostudies-arrayexpress
TranscriptomicsCav3.2 T-type calcium channel-dependent gene expression after retrieval of context-associated memory (right hippocampus)
Among all voltage-gated calcium channels, the T-type Ca2+ channels encoded by the Cav3 genes are highly expressed in the hippocampus, which is associated with contextual, temporal and spatial learning and memory. However, the specific involvement of the Cav3.2 T-type Ca2+ channel in these hippocampu...
ORGANISM(S): Mus musculus 
2013-02-28 | E-GEOD-30845 | biostudies-arrayexpress
TranscriptomicsCav3.2 T-type calcium channel-dependent gene expression after retrieval of context-associated memory (left hippocampus)
Among all voltage-gated calcium channels, the T-type Ca2+ channels encoded by the Cav3 genes are highly expressed in the hippocampus, which is associated with contextual, temporal and spatial learning and memory. However, the specific involvement of the Cav3.2 T-type Ca2+ channel in these hippocampu...
ORGANISM(S): Mus musculus 
2013-02-28 | E-GEOD-30842 | biostudies-arrayexpress
ProteomicsRepurposing E3 ubiquitin ligases as cell surface protein degraders using Proteolysis Targeting Antibodies
The majority of current therapeutics targeting plasma membrane receptors function by antagonizing ligand binding or enzymatic activities. Typical mammalian proteins, however, consist of multiple domains executing discrete but coordinated activities, and saturating inhibition of one functional domain...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-25 | MSV000089542 | MassIVE
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