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UnknownNontargeted and targeted metabolomics analysis provides novel insight into nonvolatile metabolites in Jianghua Kucha tea germplasm (Camellia sinensis var. Assamica cv. Jianghua).
Jianghua Kucha (JHKC) is a special tea germplasm with high bitterness growing in China; however, the chemical characteristics of JHKC are not completely understood. In this study, 61 differential metabolites were identified between 11 wild JHKC individuals and 3 control cultivars of Fudingdabai, Yun...
S-EPMC9040034 | biostudies-literature
UnknownComprehensive metabolic analyses provide new insights into primary and secondary metabolites in different tissues of Jianghua Kucha tea (Camellia sinensis var. assamica cv. Jianghua).

Background

Jianghua Kucha (JHKC) is a special tea germplasm with enriched specialized secondary metabolites, including theacrine, non-epimeric flavanols and methylated flavanols. Moreover, primary metabolites provide precursors and energy for the production of secondary metabolites. However,...
S-EPMC10235520 | biostudies-literature
UnknownmRNA-miRNA analyses reveal the involvement of CsbHLH1 and miR1446a in the regulation of caffeine biosynthesis in Camellia sinensis.
Caffeine, a primary flavor component in tea, has been the subject of intense research. With the goal of shedding light on the complex regulatory processes governing caffeine biosynthesis in tea plants, liquid chromatography coupled with mass spectrometry (LC-MS), transcriptomics, and small RNA analy...
S-EPMC11648165 | biostudies-literature
ProteomicsProteomic Analysis of Stationary Growth Stage and Nutritional Deficiency Adaptation Reveals Brucella Abortus Virulence Mechanisms
Brucellosis, an important bacterial zoonosis caused by Brucella species, has drawn increased attention around the world. As an intracellular pathogen, the ability of Brucella to deal with stress within the host cell is closely related to its virulence. The survival pressure on Brucella within a phag...
ORGANISM(S): Brucella abortus str. 2308 A 
2021-09-09 | PXD020869 | Pride
B. abortus  proteomics  logarithmic phase  stationary phase  nutritional stress 
ProteomicsComparative Proteomics between Brucella abortus 2308 and Genetically Marked Vaccine A19ΔvirB12 Reveal Attenuation Mechanism and Supplementary Differential Diagnosis Antigens
Brucella abortus is an important zoonotic pathogen that causes severe economic loss to husbandry and poses a threat to human health. The B. abortus A19 live vaccine has been extensively used to prevent bovine brucellosis in China. However, A19 has the limitation of diagnosis interference and residua...
ORGANISM(S): Brucella abortus (strain 2308) 
2021-09-09 | PXD022031 | Pride
B. abortus  a19δvirb12  proteomics  differential diagnosis  attenuation mechanism 
ProteomicsMecicago truncatula pulvinus proteomics
the pulvinus proteomics of Mecicago truncatula A17
ORGANISM(S): Medicago Truncatula 
2021-09-25 | PXD028750 |
UnknownCRMP2 derived from cancer associated fibroblasts facilitates progression of ovarian cancer via HIF-1α-glycolysis signaling pathway.
As the predominant stroma cells of tumor microenvironment (TME), cancer associated fibroblasts (CAFs) are robust tumor player of different malignancies. However, less is known about the regulatory mechanism of CAFs on promoting progression of ovarian cancer (OvCA). In the present study, the conditio...
S-EPMC9352901 | biostudies-literature
UnknownMonocytic myeloid-derived suppressive cells mitigate over-adipogenesis of bone marrow microenvironment in aplastic anemia by inhibiting CD8+ T cells.
Aplastic anemia (AA) is a blood disorder resulted from over-activated T-cell related hematopoietic failure, with the characterization of hypocellularity and enhanced adipogenic differentiation of mesenchymal stroma cells (MSCs) in bone marrow (BM). However, little is known about the relationship bet...
S-EPMC9293984 | biostudies-literature
UnknownOptimize individualized energy delivery for septic patients using predictive deep learning models.

Background and objectives

We aim to establish deep learning models to optimize the individualized energy delivery for septic patients.

Methods and study design

We conducted a study of adult septic patients in ICU, collecting 47 indicators for 14 days. We filtered out nutrition-related...
S-EPMC11389806 | biostudies-literature
ProteomicsCRMP2 derived from cancer associated fibroblasts facilitates progression of ovarian cancer via HIF-1α-glycolysis signaling pathway
the differntial proteins scanning between supernatent of CAFs and NOFs in ovarian cancer.
ORGANISM(S): Homo Sapiens 
2022-06-02 | PXD034266 |
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