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UnknownPathogenic and genomic characterisation of a rabbit sourced Pasteurella multocida serogroup F isolate s4.

Background

Pasteurella multocida is one of the most significant pathogens for a number of animals. In rabbits, the infection is generally associated with the P. multocida serogroups A and D, and the knowledge about the serogroup F is limited. In the present study, a P. multocida serogroup F ...
S-EPMC9308332 | biostudies-literature
UnknownNovel signature of ferroptosis-related long non-coding RNA to predict lower-grade glioma overall survival.

Background

Ferroptosis is a novel type of programmed cell death in various tumors; however, underlying mechanisms remain unclear. We aimed to develop ferroptosis-related long non-coding RNA (FRlncRNA) risk scores to predict lower-grade glioma (LGG) prognosis and to conduct functional analyse...
S-EPMC11604900 | biostudies-literature
UnknownIdentifying the long-term survival beneficiary of preoperative radiotherapy for rectal cancer in the TME era.
This study was to verify the long-term survival efficacy of preoperative radiotherapy (preRT) for locally advanced rectal cancer (LARC) patients and identify potential long-term survival beneficiary. Using the Surveillance, Epidemiology, and End Results (SEER) database, 7582 LARC patients were eligi...
S-EPMC8931157 | biostudies-literature
UnknownModified RECIST submodels and ordinal regression model predict neoadjuvant chemoimmunotherapy response in locally advanced gastric cancer​​.
This study evaluated predictive models integrating Computed Tomography(CT) and ultrasound(US) to assess neoadjuvant therapy response in locally advanced gastric cancer (LAGC). A prospective multicenter trial (n = 75) developed five RECIST 1.1-derived submodels (RECIST_Expansion, UC_RECIST, CT_RECIST...
S-EPMC12504738 | biostudies-literature
UnknownPlasma EGFR mutation ctDNA dynamics in patients with advanced EGFR-mutated NSCLC treated with Icotinib: phase 2 multicenter trial result.
Plasma epidermal growth factor receptor mutation (EGFRm) circulating tumor DNA (ctDNA) dynamics exhibit promise in predicting outcomes in patients with EGFRm-advanced non-small cell lung cancer (NSCLC). However, there remains limited trial-level data on integrating ctDNA monitoring into clinical pra...
S-EPMC11452669 | biostudies-literature
UnknownExpression and clinical implications of basic leucine zipper ATF-like transcription factor 2 in breast cancer.

Background

Basic leucine zipper ATF-like transcription factor 2 (BATF2) has been reported to participate in the occurrence and development of some malignancies. Herein, we aimed to explore the expression pattern and clinical implications of BATF2 in breast cancer (BC).

Methods

We asse...
S-EPMC8474811 | biostudies-literature
UnknownImmune system development-related signature predicts prognosis and sorafenib-treatment resistance of hepatocellular carcinoma by intergrating machine learning and single-cell analyses.
The development of the immune system (ISD) plays a pivotal role in both the genesis and progression of tumors, yet its specific functions in hepatocellular carcinoma (HCC) and the mechanisms behind sorafenib resistance remain elusive. In our investigation, we initially created 167 algorithms by amal...
S-EPMC12484598 | biostudies-literature
UnknownProline-rich acidic protein 1 upregulates mitotic arrest deficient 1 to promote cisplatin-resistance of colorectal carcinoma by restraining mitotic checkpoint complex assembly.
Background: The mechanism underlying cisplatin resistance in colorectal carcinoma (CRC) has not yet been elucidated. This study is aimed to illustrate the indispensable role of proline-rich acidic protein 1 (PRAP1) in cisplatin-resistant CRC. Methods: Cell viability and apoptosis were ...
S-EPMC10266255 | biostudies-literature
UnknownEffects of Long-Term Nitrogen Fertilization on the Formation of Metabolites Related to Tea Quality in Subtropical China.
As a main agronomic intervention in tea cultivation, nitrogen (N) application is useful to improve tea yield and quality. However, the effects of N application on the formation of tea quality-related metabolites have not been fully studied, especially in long-term field trials. In this study, a 10-y...
S-EPMC8000315 | biostudies-literature
UnknownIGHG1 upregulation promoted gastric cancer malignancy via AKT/GSK-3β/β-Catenin pathway.

Background

Despite current advances in gastric cancer treatment, disease metastasis and chemo-resistance remain as major hurdles against better overall prognosis. Previous studies indicated that IGHG1 as well as -Catenin serve as important regulators of tumor cellular malignancy. Therefore, ...
S-EPMC8314571 | biostudies-literature
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