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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
MetabolomicsEffects of MeJA on Arabidopsis metabolome under endogenous JA deficiency
Jasmonates (JAs) play important roles in plant growth, development and defense. Comprehensive metabolomics profiling of plants under JA treatment provides insights into the interaction and regulation network of plant hormones. Here we applied high resolution mass spectrometry based metabolomics appr...
2017-10-23 | MTBLS375 | MetaboLights
UnknownGANT61 suppresses proliferation and induces apoptosis in ALK-Positive anaplastic large cell lymphoma via modulating the Hh-PIK3IP1-Akt signaling axis.
Not available
S-EPMC12827395 | biostudies-literature
ProteomicsOne Brucella proteins solution sample, complete protein and 5 modifications Label-free omics research (No duplication,F8097WB remaining protein) analysis report.
Considering the role of PTMs(2-hydroxyisobutyrylation, succinylation, crotonylation, acetylation, and malonylation) in various biological processes of Brucella virulence and survival, we propose that the virulence of Brucella is associated with the PTMs of proteins. Taken together, this study provid...
ORGANISM(S): Brucella abortus (strain 2308) 
2022-03-04 | PXD030621 | Pride
Brucella 2308 lc-msms 
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
UnknownAcid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention.
Not available
S-EPMC10477349 | biostudies-literature
UnknownDevelopment of a simple and miniaturized sandwich-like fluorescence polarization assay for rapid screening of SARS-CoV-2 main protease inhibitors.
Not available
S-EPMC8645223 | biostudies-literature
UnknownSynovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis.
Not available
S-EPMC12162823 | biostudies-literature
UnknownPyrotinib and chrysin synergistically potentiate autophagy in HER2-positive breast cancer.
Not available
S-EPMC10728098 | biostudies-literature
UnknownExploratory phase II trial of an anti-PD-1 antibody camrelizumab combined with a VEGFR-2 inhibitor apatinib and chemotherapy as a neoadjuvant therapy for triple-negative breast cancer (NeoPanDa03): efficacy, safety and biomarker analysis.
Not available
S-EPMC12279984 | biostudies-literature
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