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TranscriptomicsIdentification of targets regulated by SELP in HSC
To understand the underlying mechanism by which Alox15 gene is required by HSCs, we performed a comparative DNA microarray analysis using total RNA isolated from wild type Lin-Sca-1+c-Kit+, SELP-/- Lin-Sca-1+c-Kit+. The result was validated by quantitative real-time PCR analysis of wild type Lin-Sca...
ORGANISM(S): Mus musculus 
2014-05-09 | E-GEOD-57459 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal, non-tumorigenic breast cancer cells and CD44+CD24-/low tumorigenic breast cancer cells to generate a invasiveness gene signature
Breast cancers contain a minority population of cancer cells characterized by CD44 expression but low or undetectable levels of CD24 (CD44+CD24-/low) that have higher tumorigenic capacity than other subtypes of cancer cells. METHODS: We compared the gene-expression profile of CD44+CD24-/low tumorige...
ORGANISM(S): Homo sapiens 
2007-11-02 | E-GEOD-6883 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of novel antigen presenting cells (APC) inducing pathogenic T helper cells of lupus
In lupus autoimmunity, pathogenic IgG autoantibodies that fix complement and bind FcGammaR on inflammatory cells, are produced with help from T helper (Th1 and Th17) cells specific for peptides from nucleosomes of apoptotic cells; and these Th cells also infiltrate vital organs (1-9). Macrophages (...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36284 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse prostate stem cells
The mouse prostate tissue exhibits strong power of regeneration, indicating the exisistence of prostate stem cells. Previously we showed that a single mouse prostate cells defined by Lin-CD44+CD133+Sca-1+CD117+ phenotype can generate a prostate after transplantation in vivo. In this study, we compar...
ORGANISM(S): Mus musculus 
2011-12-06 | E-GEOD-33317 | biostudies-arrayexpress
TranscriptomicsExpression profiling of primary leukemia initiating cell-enriched population induced by AML1-ETO9a
Combined gene expression and DNA occupancy profiling identifies JAK/STAT signaling as a valid therapeutic target of t(8;21) AML t(8;21) is commonly associated with acute myeloid leukemia (AML). The resulting AML1-ETO fusion proteins are involved in the pathogenesis of AML. To identify novel molecul...
ORGANISM(S): Mus musculus 
2012-09-04 | E-GEOD-15195 | biostudies-arrayexpress
UnknownPredicting Inpatient Readmission and Outpatient Admission in Elderly: A Population-Based Cohort Study.
Not available
S-EPMC4845859 | biostudies-literature
UnknownElectronegative very-low-density lipoprotein induces brain inflammation and cognitive dysfunction in mice.
Not available
S-EPMC7966811 | biostudies-literature
UnknownBlood plasma metagenomic next-generation sequencing for identifying pathogens of febrile neutropenia in acute leukemia patients.
Not available
S-EPMC10662164 | biostudies-literature
TranscriptomicsMDS and DNA repair defects in Crebbp+/- mice
Myelodysplastic syndrome (MDS) is considered a disease of hematopoietic stem cell (HSC) origin. To begin to unravel the molecular mechanisms underlying the deregulation of HSCs in MDS, we performed comparative gene expression profiling on Crebbp+/- and wild type HSCs. We chose to isolate HSCs from...
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-18061 | biostudies-arrayexpress
TranscriptomicsElevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: Implications for prostate cancer progression
Background: Aldo-keto reductase (AKR) 1C family member 3 (AKR1C3), one of four identified human AKR enzymes, catalyzes steroid, prostaglandin, and xenobiotic metabolism. In the prostate, AKR1C3 is up-regulated in localized and advanced prostate adenocarcinoma, and is associated with prostate cance...
ORGANISM(S): Homo sapiens 
2010-08-10 | E-GEOD-20956 | biostudies-arrayexpress
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