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TranscriptomicsRNA-Seq of cKIT+ sorted cells from 53-137 day old fetal testes and ovaries and RNA-Seq of TRA-1-81+ H1 and UCLA1 hESCs.
We performed RNA-Seq analyses on 15 human fetal samples at 53-137 days of development, 9 female and 5 male, and identified the transcriptional changes during the transition of human cKIT+ primordial germ cells (PGCs), the precursors of gametes, to the generation of Advanced Germline Cells. Comparing...
ORGANISM(S): Homo sapiens 
2015-05-28 | E-GEOD-63392 | biostudies-arrayexpress
GenomicsWhole Genome Bisulfite Sequencing (WGBS) of cKIT+ sorted cells from 57-137 day old fetal testes and ovaries.
We performed WGBS analyses on 6 human fetal samples at 53-137 days of development, 4 female and 2 male. We show that methylation reprogramming in the human germline is global yet incomplete with exons, 3’UTRs and human-specific transposons remaining methylated. Whole Genome Bisulfite-Seq of cKIT+ ce...
ORGANISM(S): Homo sapiens 
2015-05-28 | E-GEOD-63393 | biostudies-arrayexpress
UnknownLattice distortion enabling enhanced strength and plasticity in high entropy intermetallic alloy.
Not available
S-EPMC11310445 | biostudies-literature
GenomicsConservation and divergence of methylation patterning in plants and animals
Cytosine DNA methylation is a heritable epigenetic mark present in many eukaryotic organisms. While DNA methylation likely has a conserved role in gene silencing, the levels and patterns of DNA methylation appear to vary drastically among different organisms. Here, we used shotgun genomic bisulfite ...
ORGANISM(S): Ciona intestinalis 
2010-04-09 | E-GEOD-21152 | biostudies-arrayexpress
TranscriptomicsRelationship between nucleosome positioning and DNA methylation: ChIP-chip
Nucleosomes compact and regulate access to DNA in the nucleus, and are composed of approximately 147 bases of DNA wrapped around a histone octamer1, 2. Here we report a genome-wide nucleosome positioning analysis of Arabidopsis thaliana utilizing massively parallel sequencing of mononucleosomes. By...
ORGANISM(S): Arabidopsis thaliana 
2010-05-28 | E-GEOD-21818 | biostudies-arrayexpress
GenomicsRelationship between nucleosome positioning and DNA methylation: Bisulfite-Seq, ChIP-Seq, and Mnase-Seq
Nucleosomes compact and regulate access to DNA in the nucleus, and are composed of approximately 147 bases of DNA wrapped around a histone octamer. Here we report a genome-wide nucleosome positioning analysis of Arabidopsis thaliana utilizing massively parallel sequencing of mononucleosomes. By com...
ORGANISM(S): Homo sapiens 
2010-05-29 | E-GEOD-21821 | biostudies-arrayexpress
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