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TranscriptomicsWhole Transcriptomic Sequencing of Metastatic Castration Resistant Prostate Cancer Samples
We report the gene expression profile of 8 metastatic castration resisistant prostate cancer samples analyzed by paired-end RNA-seq. We found evidence of extensive abnormal splicing as well as several novel fusion genes. Finally, we also observed several recurrent high-confidence somatic mutations. ...
ORGANISM(S): Homo sapiens 
2014-09-06 | E-GEOD-50630 | biostudies-arrayexpress
TranscriptomicsAndrogen Receptor Gene Expression in Prostate Cancer is Directly Suppressed by the Androgen Receptor Through Recruitment of Lysine Specific Demethylase 1
Androgen receptor (AR) is reactivated in castration resistant prostate cancer (CRPC) through mechanisms including marked increases in AR gene expression. We identify an enhancer in the AR second intron contributing to increased AR expression at low androgen levels in CRPC. Moreover, at increased and...
ORGANISM(S): Homo sapiens 
2011-08-15 | E-GEOD-31410 | biostudies-arrayexpress
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