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ProteomicsToxicoproteomic Profiling of hPXR Transgenic Mice Treated with Rifampicin and Isoniazid
Tuberculosis is a global health threat that affects millions of people every year, and treatment-limiting toxicity remains a considerable source of treatment failure. Recent reports have characterized the nature of hPXR-mediated hepatotoxicity and systemic toxicity of antitubercular drugs. The antit...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-19 | PXD019505 | Pride
Anemia  antitubercular therapy  cytochrome p450  drug-induced liver injury  heme biosynthesis  hypercoagulability  iron–sulfur cluster  pellagra  vitamin b3  vitamin b6 
TranscriptomicsCarnitine palmitoyltransferase 1A (CPT1A): a transcriptional target of PAX3-FKHR and mediates PAX3-FKHR-dependent motility in alveolar rhabdomyosarcoma cells
Background: Alveolar rhabdomyosarcoma (ARMS) has a high propensity to metastasize, leading to its aggressiveness and a poor survival rate among those with the disease. More than 80% of aggressive ARMSs harbor a PAX3-FKHR fusion transcription factor, which regulates cell migration and promotes metast...
ORGANISM(S): Homo sapiens 
2012-05-15 | E-GEOD-35862 | biostudies-arrayexpress
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