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TranscriptomicsComparison of gene expression profile of naive versus arsenic trioxide resistant acute promyelocytic leukemia cell line NB4
The aim of this study was to gain insight into the potential mechanism of resistance to arsenic trioxide (ATO). The gene expression profile of naive (NB4) (Acute promyelocytic leukemia (APL) cell line and one of its in house generated ATO resistant sub clone (NB4-VM-AsR1) was done using whole genome...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-42031 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression profile of newly diagnosed versus relapse acute promyelocytic leukemia
The aim of this study was to gain insight into the potential mechanism of resistance to arsenic trioxide and to identify genes that are modulated in the malignant promyelocytes at the time of relapse in APL patients. We analyzed the gene expression profile by the whole genome microarray of primary p...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-42030 | biostudies-arrayexpress
TranscriptomicsComprehensive mutational analysis of primary and relapse acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is a subtype of myeloid leukemia characterized by differentiation block at the promyelocyte stage. Besides the presence of chromosomal rearrangement t(15;17) leading to formation of PML-RARA fusion, other genetic alterations have also been implicated in APL. ...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-77946 | biostudies-arrayexpress
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