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TranscriptomicsAn EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.
Regulation of cell-cell junction formation and regulation of cell migration were enriched among EMT (Epithelial-Mesenchymal Transition)-associated alternatively splicing events. Our analysis suggested that most EMT-associated alternative splicing events are regulated by one or more members of the RB...
ORGANISM(S): Homo sapiens 
2011-07-15 | E-GEOD-30290 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression between MEFs and induced embryonic Sertoli-like cells
To compare the the genomic profile of MEFs and induced embryonic Sertoli-like cells following 2 weeks of dox withdrawal. ieSCs (from MEFs and from TTFs) and MEF control were grown in F12/DMEM medium without dox for two weeks.
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-39650 | biostudies-arrayexpress
TranscriptomicsGene expression comparison between different stages of endogenous Sertoli cells and induced embryonic Sertoli cells derived from MEFs and TTFs
To compare the transcriptional profile of endogenous Sertoli cells from different Stage of Sertoli cell development (embryonic, immature, mature) to the transcriptionla profile of induced embryonic Sertoli cells derived from MEFs or TTFs we employed the agilent whole genome microarray Keywords: Exp...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-39648 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression between MEFs, MEFs (NWD), immature Sertoli cells and mature Sertoli cells
To compare the the genomic profile of MEFs, immature Sertoli, mature Sertoli cells, and MEFs (NWD) after infection of Nr5a1, Wt1 and Dmrt1 after 1 month of dox exposure. MEFs (NWD) were infected with Nr5a1, Wt1 and Dmrt1 and were exposed to dox for 1 month. MEFs, immature Sertoli and mature Sertoli ...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-39649 | biostudies-arrayexpress
TranscriptomicsDirect reprogramming of fibroblasts into embryonic Sertoli-like cells by defined factors
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-35653 | biostudies-arrayexpress
TranscriptomicsThe X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex specific manner [Agilent array data]
Embryogenesis requires the timely and coordinated activation of developmental regulators. It has been suggested that the recently discovered class of histone demethylases (UTX and JMJD3) that specifically target the repressive H3K27me3 modification play an important role in the activation of M-bM-^...
ORGANISM(S): Mus musculus 
2012-07-31 | E-GEOD-39473 | biostudies-arrayexpress
TranscriptomicsThe X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex specific manner
This SuperSeries is composed of the following subset Series: GSE39472: X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner [ChIP-Seq data] GSE39473: The X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex specific manner [Agil...
ORGANISM(S): Mus musculus 
2012-07-31 | E-GEOD-39222 | biostudies-arrayexpress
TranscriptomicsGene expression profile of Tet1 knockout mouse embryonic stem cells (mESCs)
Global gene expression profile of Tet1 knockout ES cells is compared to wild-type ES cells. All ES lines used are V6.5 (mix 129 C57BL6 backgound). 2 Tet1 KO mice compared to 1 Tet1 wild type mouse.
ORGANISM(S): Mus musculus 
2011-07-31 | E-GEOD-30748 | biostudies-arrayexpress
TranscriptomicsGene Expression Data for Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations
Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease in disease relevant cells, as well as a promising source for cell replacement therapies for degenerative diseases. However one of the crucial limitations before rea...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-29773 | biostudies-arrayexpress
TranscriptomicsCNV analysis for Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations
Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease in disease relevant cells, as well as a promising source for cell replacement therapies for degenerative diseases. However one of the crucial limitations before rea...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-29772 | biostudies-arrayexpress
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