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GenomicsA role for H3K4 mono-methylation in facultative heterochromatin assembly and partitioning of chromatin readers
Mono-methylation of lysine 4 on histone H3 (H3K4me1) is a well-established feature of enhancers and promoters, although its function is unknown. Remarkably, we find H3K4me1 at the promoter regions of conditionaly-repressed muscle and stimulus-dependent inflammatory response genes in myoblasts. Durin...
ORGANISM(S): Mus musculus 
2014-03-29 | E-GEOD-50590 | biostudies-arrayexpress
GenomicsGenome-wide maps of Sin3A and Sin3B binding in C2C12 myoblasts and differentiated myotubes
Sin3A and Sin3B bind to distinct and overlapping target sites. Sin3 proteins bind to distinct sites in cycling myoblasts whereas there is a converge of Sin3A and Sin3B proteins to sites in differentiated myotubes. We identified a subset of Sin3 target genes involved in muscle differentiation and phy...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-22554 | biostudies-arrayexpress
GenomicsGenome-wide remodeling of the epigenetic landscape during myogenic differentiation
We have examined changes in the chromatin landscape during muscle differentiation by mapping the genome-wide location of ten key histone marks and transcription factors in mouse myoblasts and terminally differentiated myotubes, providing an exceptionally rich dataset that has enabled discovery of ke...
ORGANISM(S): Mus musculus 
2011-05-08 | E-GEOD-25308 | biostudies-arrayexpress
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