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TranscriptomicsGlobal transcriptomic profiling of lactacystin-mediated neuronal death
Inhibition of proteasome degradation pathway has been implicated in neuronal cell death leading to neurodegenerative diseases such as ParkinsonM-bM-^@M-^Ys disease and AlzheimerM-bM-^@M-^Ys disease. Pharmacological proteasomal inhibitors such as lactacystin can induce apoptosis in cultured mouse co...
ORGANISM(S): Mus musculus 
2012-01-03 | E-GEOD-22465 | biostudies-arrayexpress
TranscriptomicsGlobal gene profiling comparison between hydrogen sulfide- and N-methyl-D-aspartate-induced neuronal deaths
Hydrogen sulfide (H2S), present in abundance in the mammalian brain, has recently been demonstrated to induce a dose- and time-dependent apoptotic-necrotic continuum in murine primary cortical neurons, which was successfully attenuated upon application of N-methyl-D-aspartate (NMDA) receptor antagon...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-16035 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomic profiling of nitric oxide-mediated neuronal death
Nitric oxide (NO) is implicated in the pathogenesis of various neuropathologies characterised by oxidative stress. NO has been reported to be involved in the exacerbation of oxidative stress by various mechanisms, including protein modification, genotoxic damage and elevated production of reactive o...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-22087 | biostudies-arrayexpress
TranscriptomicsComparative global transcriptomic profiling of low and high concentration of lactacystin-mediated neuronal death
Inhibition of proteasome degradation pathway has been implicated in neuronal cell death leading to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease. Pharmacological proteasomal inhibitors such as lactacystin can induce apoptosis in cultured mouse cortical neurons throu...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-23155 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomic profiling of oxygen-glucose deprivation (OGD)-mediated neuronal injury
Oxygen-glucose deprivation (OGD) is a cellular phenomenon consistently observed upon occurrence of ischemic stroke which eventually results in neuronal death. Neuronal cell death after ischemia takes place via two distinct processes, necrosis and apoptosis. Apoptosis, programmed cell death, is denot...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-23158 | biostudies-arrayexpress
TranscriptomicsGlobal gene profiling of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-induced neuronal death
AMPA receptors are involved not only in neuronal plasticity but also in excitotoxicity, mediated largely by the influx of Ca2+ (Choi et al., 1988). Their implication has been highlighted in animal models of ischemia and epilepsy. Studies of ischemic rodent models featured that prior to cell death, h...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-22993 | biostudies-arrayexpress
TranscriptomicsGlobal gene profiling of kainate-induced neuronal death
It has long been established that in neurological disease models, KA is a potent excitotoxin, mediating acute limbic seizures and long-term morphologic changes in the hippocampus, which are hallmark characteristics seen in temporal lobe epilepsy (i.e. mossy-fiber sprouting, neuronal loss, and reacti...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-22994 | biostudies-arrayexpress
TranscriptomicsGlobal gene profiling of (-)-Epigallocatechin-3-gallate (EGCG)-induced neuronal death
Alzheimer’s disease (AD) is the most common form of adult-onset dementia with severe intellectual deterioration and is characterised by the accumulation of the amyloid-β (Aβ) peptides and the presence of hyperphosphorylated microtubule- associated protein, tau. (-)-Epigallocatechin-3-gallate (EGCG) ...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-22996 | biostudies-arrayexpress
TranscriptomicsGlobal gene profiling of glutamate-induced neuronal death
Glutamate, a major neurotransmitter in the mammalian nervous sytem, has been involved in the mediation of excitotoxicity commonly observed in the pathogenesis of stroke. Current study focused on gaining an insight into the molecular mechanisms of glutamate-induced neuronal death A total of 15 RNA sa...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-19936 | biostudies-arrayexpress
TranscriptomicsGlobal gene profiling of rotenone-induced neuronal death
Rotenone is a naturally occurring toxic substance from the Leguminosa plant and belongs to the group of compounds known as rotenoids (Bové et al., 2005). It is commercially used as a pesticide and is epidemiologically linked to PD. Being lipophilic, rotenone can diffuse across biological membranes ...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-22997 | biostudies-arrayexpress
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