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MetabolomicsMultiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to probe the interplay of proteins and lipids in synaptic signal t...
2021-09-27 | MTBLS1531 | MetaboLights
TranscriptomicsGene expression from CEPH-Utah,CHB+JPT, and YRI individuals to examine gene expression correlation
We used microarrays to examine gene expression levels in individuals from different populations (cephgp, chb, jpt, yri). The chb and jpt populations are combined in the analysis. We measured gene expression levels in 295 lymphoblastoid cell lines representing 4 ethnically-distinct populations. For...
ORGANISM(S): Homo sapiens 
2009-08-13 | E-GEOD-12526 | biostudies-arrayexpress
TranscriptomicsNatural variation in human gene expression assessed in lymphoblastoid cells
Lymphoblastoid cells from 35 unrelated individuals used to examined variation in gene expression. Identified genes whose transcript levels differed greatly among unrelated individuals.
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-137 | biostudies-arrayexpress
TranscriptomicsRole of the accessory gene regulator agr in community-associated MRSA pathogenesis
The success of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) as pathogens is due to a combination of antibiotic resistance with high virulence. However, evolution of the exceptional virulence potential of CA-MRSA is not understood. Our previous study indicated that diffe...
ORGANISM(S): Staphylococcus aureus 
2011-03-29 | E-GEOD-18793 | biostudies-arrayexpress
TranscriptomicsGene expression levels in immortalized B cells from members of 45 CEPH-Utah pedigrees
We used microarrays to examine gene expression levels from members of 45 CEPH-Utah pedigrees. Keywords: array-based gene expression We measured gene expression levels in immortalized B cells from members of 45 CEPH-Utah pedigrees. For some cell lines, RNA extracts were hybridized twice, representi...
ORGANISM(S): Homo sapiens 
2010-09-21 | E-GEOD-16778 | biostudies-arrayexpress
TranscriptomicsPolymorphic cis- and trans-regulation of human gene expression
Expression levels of human genes vary extensive among individuals. Gene expression determines cell function and characteristics thus this variation likely contributes to phenotypic variation. Genetic studies have shown that there is a heritable component to gene expression variation, and have iden...
ORGANISM(S): Homo sapiens 
2010-09-19 | E-GEOD-16921 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila Myb-MuvB/dREAM
Myb-MuvB (MMB)/dREAM is a nine subunit complex first described in Drosophila as a repressor of transcription, dependent upon E2F2 and the RBFs. Myb, an integral member of MMB, curiously plays no role in the silencing of the test genes previously analyzed. Moreover, Myb plays an activating role in DN...
ORGANISM(S): Drosophila melanogaster 
2008-06-16 | E-GEOD-8751 | biostudies-arrayexpress
TranscriptomicsHIT analysis of T cells activated in the presence of TGF-β
We have developed a multi-analyte fluid-phase protein array technology termed high-throughput immunophenotyping using transcription (HIT). This method employs a panel of monoclonal antibodies, each tagged with a unique oligonucleotide sequence that serves as a molecular barcode. After staining a s...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10762 | biostudies-arrayexpress
TranscriptomicsHIT: a new versatile protein array platform for multi-analyte phenotyping of surface molecules
We have developed a multi-analyte fluid-phase protein array technology termed high-throughput immunophenotyping using transcription (HIT). This method employs a panel of monoclonal antibodies, each tagged with a unique oligonucleotide sequence that serves as a molecular barcode. After staining a s...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10665 | biostudies-arrayexpress
TranscriptomicsHIT T cell versus B cell line proof-of-principle
We have developed a multi-analyte fluid-phase protein array technology termed high-throughput immunophenotyping using transcription (HIT). This method employs a panel of monoclonal antibodies, each tagged with a unique oligonucleotide sequence that serves as a molecular barcode. After staining a s...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10761 | biostudies-arrayexpress
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