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TranscriptomicsRaptor/mTORC1-dependent metabolic programming of exit from quiescence underlies T cell activation and fate decisions
Naïve T cells respond to antigen stimulation by exiting from quiescence into clonal expansion and functional differentiation, but the control mechanism is elusive. Here we describe that Raptor/mTORC1-dependent metabolic reprogramming is a central determinant of this transitional process. Loss of Rap...
ORGANISM(S): Mus musculus 
2014-01-27 | E-GEOD-51668 | biostudies-arrayexpress
TranscriptomicsHIF1a-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Upon antigen stimulation, the bioenergetic demands of T cells increase dramatically over the resting state. Although a role for the metabolic switch to glycolysis has been suggested to support increased anabolic activities and facilitate T cell growth and proliferation, whether cellular metabolism c...
ORGANISM(S): Mus musculus 
2011-06-07 | E-GEOD-29765 | biostudies-arrayexpress
TranscriptomicsmTORC1 couples immune signals and metabolic programming to establish Treg cell function
The mechanistic target of rapamycin (mTOR) pathway integrates diverse environmental inputs, including immune signals and metabolic cues, to direct T cell fate decisions1. Activation of mTOR, comprised of mTORC1 and mTORC2 complexes, delivers an obligatory signal for proper activation and differentia...
ORGANISM(S): Mus musculus 
2013-06-24 | E-GEOD-46693 | biostudies-arrayexpress
TranscriptomicsTAK1-dependent checkpoint in dendritic cell survival regulates immune homeostasis and function
Homeostatic control of dendritic cell (DC) survival is crucial for a productive adaptive immune response, but the molecular mechanism is not well defined. Moreover, how DCs influence homeostasis of the immune system under steady state remains unclear. Combining DC-specific and inducible deletion sys...
ORGANISM(S): Mus musculus 
2012-01-23 | E-GEOD-34417 | biostudies-arrayexpress
TranscriptomicsTsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs
Memory CD8+ T cells are an essential component of protective immunity. Signaling via mechanistic target of rapamycin (mTOR) has been implicated in the regulation of the differentiation of effector and memory T cells. However, little is understood about the mechanisms that control mTOR activity, or t...
ORGANISM(S): Mus musculus 
2014-09-20 | E-GEOD-61591 | biostudies-arrayexpress
ProteomicsDeep Multilayer Tissue Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression, human data
The molecular networks underlying Alzheimer’s disease (AD) are not well-defined. We present temporal profiling of >14,000 proteins and >34,000 phosphosites at the asymptomatic and symptomatic stages of AD, deep proteomics analysis of transgenic mouse models.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-17 | MSV000096123 | MassIVE
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