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TranscriptomicsSmooth Muscle Cells
This set contains 68 arrays of two series of experiments. 60 arrays are used to profile the heterogeneity of SMCs from different anatomic locations. 8 arrays are used to profile the change of gene expression of vascular smooth muscle cells upon serum exposure. An all pairs experiment design type is ...
ORGANISM(S): Homo sapiens 
2007-09-27 | E-GEOD-7195 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fibroblasts to examine diversity, topographic differentiation and positional memory
Diversity, Topographic Differentiation, and Positional Memory in Human Fibroblasts Howard Y. Chang, Jen-Tsan Chi, Sandrine Dudoit, Chanda Bondre, Matt van de Rijn, David Botstein, and Patrick O. Brown A fundamental feature of the architecture and functional design of vertebrate animals is a stroma...
ORGANISM(S): Homo sapiens 
2005-09-27 | E-SMDB-1507 | biostudies-arrayexpress
TranscriptomicsEndothelial cell diversity revealed by global expression profiling
The vascular system is locally specialized to accommodate widely varying blood flow and pressure and the distinct needs of individual tissues. The endothelial cells (ECs) that line the lumens of blood and lymphatic vessels play an integral role in the regional specialization of vascular structure an...
ORGANISM(S): Homo sapiens 
2005-12-20 | E-GEOD-3874 | biostudies-arrayexpress
TranscriptomicsThe genomic analysis of the interaction between the lactic acidosis and hypoxia response
Lactic acidosis and hypoxia are two prominent tumor microenvironmental stresses that are both known to exert important influences on gene expression and phenotypes of cancer cells. But very little is known about the cross-talk and interaction between these two stresses. We performed gene expression ...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-29406 | biostudies-arrayexpress
TranscriptomicsScleroderma Architecture Cell Lines
The data from these cell lines is described in figure 2 of the mansucript "Systemic and cell-type specific gene expression patterns in scleroderam skin" by Whitfield et al. (2003) PNAS. Aortic smooth muscle cells and microvascular endothelial cells were obtained from Clonetics and culture...
ORGANISM(S): Homo sapiens 
2005-12-20 | E-GEOD-3887 | biostudies-arrayexpress
TranscriptomicsAscites enriches for ovarian cancer stem-like cells that express membrane GRP78
Ovarian cancer patients are generally diagnosed at stage III/IV, when ascites is common. The volume of ascites positively correlates with the extent of metastasis and negatively with prognosis. Membrane GRP78, a stress-inducible endoplasmic reticulum chaperone which also appears on the plasma membra...
ORGANISM(S): Mus musculus 
2015-03-09 | E-GEOD-61285 | biostudies-arrayexpress
TranscriptomicsThe genomic analysis of erythrocyte microRNA expression in sickle cell diseases
Background Since mature erythrocytes are terminally differentiated cells without nuclei and organelles, it is commonly thought that they do not contain nucleic acids. In this study, we have re-examined this issue by analyzing the transcriptome of a purified population of human mature erythrocytes fr...
ORGANISM(S): Homo sapiens 
2009-04-04 | E-GEOD-11060 | biostudies-arrayexpress
TranscriptomicsPAX3-FOXO1 suppresses cellular senescence through RASSF4-mediated restraint of the mammalian Hippo/MST1 pathway
Alveolar rhabdomyosarcoma (aRMS) is an aggressive sarcoma of skeletal muscle characterized by expression of the PAX3-FOXO1 fusion gene. Despite its discovery over almost 20 years ago, PAX3-FOXO1 remains an enigmatic tumor driver. Previously, we reported that PAX3-FOXO1 supports aRMS initiation by en...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-40543 | biostudies-arrayexpress
TranscriptomicsShort and Long RNA sequencing of human mature erythrocytes
We employed high-throughput sequencing of both short (~18-24nt) and long (>200nt) RNAs in human erythrocytes. We obtained blood from five healthy individuals for the short (small) RNA-seq library preparations and blood from three individuals for the long RNA-seq library preparations. We identified a...
ORGANISM(S): Homo sapiens 
2015-11-19 | E-GEOD-63703 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of response to Hypoxia, cell type specificity and prognostic significance in human cancers
This 58 arrays are the basis of our hypoxia story published in PLoS Medicine. The cell type, oxygen tension and time points are indicated.
ORGANISM(S): Homo sapiens 
2006-06-06 | E-SMDB-3611 | biostudies-arrayexpress
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