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GenomicsH3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence (ChIP-seq)
Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest. We combined quantitative mass spectrometry and ChIP deep-sequencing to identify changes in histone modification occurring ...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-43921 | biostudies-arrayexpress
GenomicsGenome wide maps of E2F7 binding in IMR90 cells
Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F t...
ORGANISM(S): Homo sapiens 
2012-08-25 | E-GEOD-40343 | biostudies-arrayexpress
GenomicsH3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-43922 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human IMR90 cells after RNAi suppression of RB, p107 or p130 using in growing, quiescent or ras-induced senescent IMR90 cells
The action of RB as a tumor suppressor has been difficult to define, in part, due to the redundancy of the related proteins p107 and p130. By coupling advanced RNAi technology to suppress RB, p107 or p130 with a genome wide analysis of gene expression in growing, quiescent or ras-senescent cells, we...
ORGANISM(S): Homo sapiens 
2010-01-23 | E-GEOD-19864 | biostudies-arrayexpress
GenomicsGenome wide maps of p53 binding in IMR90 cells
Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F t...
ORGANISM(S): Homo sapiens 
2012-12-05 | E-GEOD-42728 | biostudies-arrayexpress
GenomicsGenome-wide analysis of RB and p130 binding in human diploid fibroblasts
The action of RB as a tumor suppressor has been difficult to define, in part, due to the redundancy of the related proteins p107 and p130. By coupling advanced RNAi technology with a genome wide analysis of gene expression and RB chromatin binding, we identified a unique and specific activity of RB ...
ORGANISM(S): Homo sapiens 
2010-01-15 | E-GEOD-19898 | biostudies-arrayexpress
TranscriptomicsH3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence (expression)
Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest. We have examined the effect of suppressing the histone demethylases Jarid1a and Jarid1b on the senescence-associated gene ...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-43920 | biostudies-arrayexpress
TranscriptomicsExpression data from either growing IMR90 human fibroblasts or senescent IMR90 cells with Ras expression and indicated hairpins
Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F t...
ORGANISM(S): Homo sapiens 
2012-08-25 | E-GEOD-40349 | biostudies-arrayexpress
TranscriptomicsExpression data from Em-Myc mouse lymphomas
Ezh2 encodes for the catalyc unit of the PRC2 complex. RNAi-mediated suppressing of Ezh2 by two independent shRNAs promotes Em-myc lymphomagenesis in vivo. Microarray were used to explore the trascriptional changes driven by suppression of Ezh2 in Em-myc cells and to identify which programs contribu...
ORGANISM(S): Mus musculus 
2015-02-01 | E-GEOD-64537 | biostudies-arrayexpress
TranscriptomicsMutant p53 Disrupts Mammary Acinar Morphogenesis via the Mevalonate Pathway
p53 is a frequent target for mutation in human tumors and previous studies have revealed that these missense mutant proteins can actively contribute to tumorigenesis. To elucidate how mutant p53 might contribute to mammary carcinogenesis we employed a three-dimensional (3D) culture model. In 3D cul...
ORGANISM(S): Homo sapiens 
2012-02-13 | E-GEOD-31812 | biostudies-arrayexpress
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