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Coordinate tumor-antigen uptake and dendritic cell activation by chimeric antigen receptors. [RNA-seq]
Coordinate tumor-antigen uptake and dendritic cell activation by chimeric antigen receptors. [TCR-seq]

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
Sequence and structural determinants of efficacious de novo chimeric antigen receptors
Co-STARs: Combining the advantages of chimeric antigen and T cell receptors for cancer targeting
Coordinate tumor-antigen uptake and dendritic cell activation by chimeric antigen receptors.
Comparison of Transcriptional Profiles of T cells after Activation by TCR and Chimeric Antigen Receptors
RNA-seq profile of stimulated Tregs containing co-receptor signaling domain variant chimeric antigen receptors (CARs).
Optimized delivery of dual co-stimulation and anti-tumor activity using parallel chimeric antigen receptors (pCARs)
IgG cytoplasmic tail interferes with the induction of antigen-response genes Experiment Overall Design: Comparing antigen-induced genes between B cells expressing anti-HEL IgM BCR and IgMG BCR (chimeric receptor where the extracellular spacer, transmembrane, and cytoplasmic domain of IgM are replace...
ORGANISM(S): Mus musculus 
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