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TranscriptomicsStudying the effects of the TEN1-ICD on transcriptional regulation
Teneurins are large type II transmembrane proteins that are necessary for the normal development of the central nervous system (CNS). While many studies highlight the significance of teneurins, especially during development, there is only limited information known about the molecular mechanisms of f...
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-61704 | biostudies-arrayexpress
TranscriptomicsComparing the effects of MITF on transcriptional regulation to the TEN1-ICD
We identified histidine triad nucleotide binding protein 1 (HINT1) as a human teneurin-1 ICD interaction partner in a yeast-2 hybrid screen. This interaction was confirmed in human cells, where HINT1 is known to inhibit the transcription of target genes by directly binding to transcription factors a...
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-61705 | biostudies-arrayexpress
TranscriptomicsMKL1-dependent tenascin-C transcription
The aim of the experiment is to investigate whether megakaryoblastic leukemia factor-1 (MKL1) induces tenascin-C in normal mammary epithelial HC11 and tumor mammary epithelial 4T1 cell lines, as well as to identify other genes that are transcriptionally regulated by MKL1. For this purpose, we compar...
ORGANISM(S): Mus musculus 
2011-06-10 | E-MEXP-3232 | biostudies-arrayexpress
TranscriptomicsComparison of tenascin-C proficient versus tenascin-C deficient Mouse Embryonic Fibroblasts (MEFs)
In order to investigate what signalling pathways are turned on by tenascin-C, we generated Mouse Embryonic Fibroblasts (MEFs) deficient for tenascin-C and compared their gene expression profile to MEFs proficient for tenascin-C. TNC-KO MEFs as well as WT MEFs in which tenascin-C was knocked-down (fo...
ORGANISM(S): Mus musculus 
2011-02-22 | E-GEOD-23547 | biostudies-arrayexpress
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