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ProteomicsRepurposing the antiplatelet drug prasugrel for Parkinson’s disease: Evidence of neuroprotective effects and proteomic profiles
Chronic neuroinflammation is a hallmark pathological feature of Parkinson’s disease (PD) that contributes to progressive neuronal death. Current medications are largely palliative, underscoring the need for alternative therapeutic strategies. Drug repurposing offers a cost-effective and time-efficie...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2026-07-16 | PXD076315 | Pride
Prasugrel Drug repurposing Proteomics Parkinson’s disease 
TranscriptomicsmRNA expression profile in vascular smooth muscle cells (VSMCs) after inducing calcification
Vascular calcification (VC) is often associated with cardiovascular and metabolic diseases. However, the molecular mechanisms linking VC to these diseases have yet to be elucidated. Here we report that MDM2-induced polyubiquitination of histone deacetylase 1 (HDAC1) mediates VC. Loss of HDAC1 activi...
ORGANISM(S): Rattus norvegicus 
2015-11-07 | E-GEOD-74755 | biostudies-arrayexpress
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