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ProteomicsTissue extracellular matrix hydrogels as alternative to Matrigel for culturing gastrointestinal organoid
Matrigel, a mouse tumor extracellular matrix (ECM) protein mixture, is an indispensable component of most organoid tissue culture. However, it has limited the utility of organoids for drug development and regenerative medicine due to its tumor-derived origin, batch-to22 batch variation, high cost, a...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-01-31 | PXD023705 | Pride
Gastrointestinal organoid Tissue extracellular matrix 
ProteomicsCombination of a microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
Brain organoids derived from human pluripotent stem cells provide a highly valuable in vitro model to recapitulate human brain development and neurological diseases. However, the current systems for brain organoid culture require further improvement for the reliable production of high-quality organo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Sus scrofa domesticus (domestic pig) 
2021-06-02 | PXD025397 | Pride
Brain extracellular matrix Microfluidic device Organoid 
ProteomicsVersatile human cardiac tissues engineered with perfusable heart extracellular microenvironment for biomedical applications
Engineered human cardiac tissues have been utilized for various biomedical applications, including drug testing, disease modeling, and regenerative medicine. However, the applications of cardiac tissues derived from human pluripotent stem cells are often limited due to their immaturity and lack of f...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-02-03 | PXD042077 | Pride
Decellularization 
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