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GenomicsProteogenomics analysis reveals specific genomic orientations at distal regulatory regions composed by non-canonical histone variants
Histone variants (H3.1, H3.3, H2A, and macroH2A) were studied about their proteomic and genomic distribution in Hela cells HeLa S3 cells stably expressing either FLAG-tagged H3.1, and H3.3 were grown in suspension in Joklik media containing 10% newborn calf serum (Hyclone), 1% GlutaMAX (Invitrogen),...
ORGANISM(S): Homo sapiens 
2015-12-22 | E-GEOD-64652 | biostudies-arrayexpress
GenomicsSpecific mitotic chromatin association of the major notch effector RBPJ and its implication for transcriptional memory
From the cell-based investigation, RBPJ is one of the few proteins retained on chromatin during cell division. ChIP-seq experiments were performed to understand the binding pattern of RBPJ between interphase and mitosis and to identify the genes requiring RBPJ binding for the maintenance of transcri...
ORGANISM(S): Mus musculus 
2014-05-14 | E-GEOD-45889 | biostudies-arrayexpress
UnknownEnhanced therapeutic potential of antibody fragment via IEDDA-mediated site-specific albumin conjugation.
Not available
S-EPMC10996255 | biostudies-literature
GenomicsHDAC3-dependent regulation of H3K9 acetylation in IECs
The development and severity of inflammatory bowel diseases (IBD) and other chronic inflammatory conditions can be influenced by host genetic and environmental factors, including signals derived from commensal bacteria. However, the mechanisms that integrate these diverse cues remain undefined. Her...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-50453 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulation of the MEG3-DLK1 microRNA cluster in human Type 2 diabetic islets
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing β-cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs o...
ORGANISM(S): Homo sapiens 
2013-11-22 | E-GEOD-51924 | biostudies-arrayexpress
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