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ProteomicsProteomic Analysis of Extracellular Vesicles Derived from Human Pluripotent Stem Cells
Extracellular vesicles (EVs) and secretory factors are key to intercellular communication, yet their molecular dynamics in human pluripotent stem cells (hPSCs) are not well understood. We identified a key EV surface protein that regulates hPSC stemness, enhances growth, and promotes EV endocytosis. ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-14 | PXD056373 | Pride
Extracellular vesicles Human pluripotent stem cells 
GenomicsAKT phosphorylates H3-threonine 45 to facilitate termination of gene transcription in response to DNA damage.
Purpose: In this study, we show that DNA damage-activated AKT phosphorylates threonine 45 of core histone H3 (H3-T45) Result: By genome-wide chromatin immunoprecipitation sequencing (ChIP-seq) analysis, H3-T45 phosphorylation was distributed throughout DNA damage-responsive gene loci, particularly i...
ORGANISM(S): Homo sapiens 
2015-04-09 | E-GEOD-67699 | biostudies-arrayexpress
ProteomicsFormaldehyde-crosslinking enables comprehensive profiling of in vivo RNA-interactome in UV-impermeable samples
Development of UV-crosslinking based RNA-interactome capture protocol have expanded the repertoire of RBPs. Apparent limitations of UV-crosslinking, however, have made the RBP profiling to be incomplete and inapplicable to many of the biological samples in physiological contexts. Here we developed f...
ORGANISM(S): Homo sapiens (Human) Xenopus laevis (African clawed frog) 
2020-11-25 | PXD010046 | Pride
Rbp formaldehyde 
Proteomicsintercardiac Phosphoproteome/proteome regulation of cardiomyocyte-fibroblast signaling
Secretome-mediated signaling from human iPSC-derived cardiomyocytes (TGF-beta induced dysfunction) to primary human cardiac fibroblasts was investigated to identify downstream regulators of fibrosis. Quantitative proteomic profiling revealed a dynamic reprogramming of fibroblast global proteome, wit...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-27 | MSV000092293 | MassIVE
GenomicsThese are from Korean HCC samples with exome sequencing
Hepatic resection is the most curative treatment option for early-stage hepatocellular carcinoma, but is associated with a high recurrence rate, which exceeds 50% at 5 years after surgery. Understanding the genetic basis of hepatocellular carcinoma at surgically curable stages may enable the identif...
EGAS00001000604 | EGA
UnknownPreventive Measures and Risk Factors for Post-ERCP Pancreatitis: A Systematic Review and Individual Patient Data Meta-Analysis.
Not available
S-EPMC11602798 | biostudies-literature
UnknownAn evidence map on traditional medicine across health outcomes.
Not available
S-EPMC11364122 | biostudies-literature
UnknownThe 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms.
Not available
S-EPMC9252913 | biostudies-literature
UnknownMeta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
Not available
S-EPMC4737645 | biostudies-literature
UnknownMediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke.
Not available
S-EPMC10762575 | biostudies-literature
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