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UnknownTreat-to-target versus high-intensity statin treatment in patients with or without diabetes mellitus: a pre-specified analysis from the LODESTAR trial.

Background

The impact of titrated versus fixed intensity statin therapy in patients with coronary artery disease (CAD) and diabetes mellitus (DM) remains to be elucidated.

Methods

This was a pre-specified analysis of patients with and without DM from the LODESTAR trial. Patients with ...
S-EPMC10520306 | biostudies-literature
UnknownEffect of rosuvastatin versus atorvastatin on new-onset diabetes mellitus in patients treated with high-intensity statin therapy for coronary artery disease: a post-hoc analysis from the LODESTAR randomized clinical trial.

Background

The impact of rosuvastatin versus atorvastatin on new-onset diabetes mellitus (NODM) among patients treated with high-intensity statin therapy for coronary artery disease (CAD) remains to be clarified. This study aimed to evaluate the risk of NODM in patients with CAD treated with...
S-EPMC11304915 | biostudies-literature
UnknownRelationship between Arachidonate 5-Lipoxygenase-Activating Protein Gene and Peripheral Arterial Disease in Elderly Patients Undergoing General Surgery: A Retrospective Observational Study.
Patients with peripheral arterial disease (PAD) are at a higher risk of developing postoperative complications. Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) plays an important role in atherosclerosis pathogenesis. In this study, the relationship between PAD and several single nucleotide ...
S-EPMC9858772 | biostudies-literature
UnknownAlleviation of ER stress via targeted genetic engineering enhances recombinant ovalbumin secretion in <i>Saccharomyces cerevisiae</i>.
Enhancing the secretion of heterologous proteins in Saccharomyces cerevisiae is often hindered by endoplasmic reticulum (ER) stress and inefficiencies in intracellular trafficking. To address these limitations, we systematically evaluated 14 genetic modifications associated with the secretory...
S-EPMC12799817 | biostudies-literature
UnknownDistinct effects of SIRT1 in cancer and stromal cells on tumor promotion.
The lysyl deacetylase SIRT1 acts as a metabolic sensor in adjusting metabolic imbalance. To explore the role of SIRT1 in tumor-stroma interplay, we designed an in vivo tumor model using SIRT1-transgenic mice. B16F10 mouse melanoma grew more quickly in SIRT1-transgenic mice than in wild-type mice, wh...
S-EPMC5029678 | biostudies-literature
UnknownAssociation between the Persistence of Obesity and the Risk of Gastric Cancer: A Nationwide Population-Based Study.

Purpose

There remains controversy about relationship between obesity and gastric cancer. We aimed to examine the association using obesity-persistence.

Materials and methods

We analyzed a nationwide population-based cohort which underwent health check-up between 2009 and 2012. Among t...
S-EPMC8756136 | biostudies-literature
UnknownVGF and the VGF-derived peptide AQEE30 stimulate osteoblastic bone formation through the C3a receptor.
New therapeutic targets, especially those that stimulate bone formation in cortical bone, are needed to overcome the limitations of current antiosteoporotic drugs. We previously demonstrated that factors secreted from megakaryocytes (MKs) promote bone formation. Here we conducted a proteomic analysi...
S-EPMC11958639 | biostudies-literature
UnknownImpact of Smoking and Alcohol Consumption on Early-Onset Gastric Cancer Development in Young Koreans: A Population-Based Study.

Purpose

Although smoking and alcohol consumption are known risk factors for gastric cancer (GC), studies assessing their effects on early-onset GC are limited. In this nationwide, population-based, prospective cohort study, we assessed the effects of smoking and alcohol consumption on early-...
S-EPMC10995832 | biostudies-literature
UnknownMMP9 processing of HSPB1 regulates tumor progression.
Matrix metalloproteinases regulate pathophysiological events by processing matrix proteins and secreted proteins. Previously, we demonstrated that soluble heat shock protein B1 (HSPB1) is released primarily from endothelial cells (ECs) and regulates angiogenesis via direct interaction with vascular ...
S-EPMC3896397 | biostudies-literature
UnknownThe Persistence of Hypertriglyceridemia and the Risk of Early Onset Colorectal Cancer According to Tumor Subsites: A Nationwide Population-Based Study.

Purpose

The incidence of early-onset colorectal cancer (EoCRC) is increasing worldwide. The association between hypertriglyceridemia (HTG) and EoCRC risk remains unclear.

Materials and methods

We conducted a nationwide cohort study of 3,340,635 individuals aged 20-49 years who underwe...
S-EPMC11261183 | biostudies-literature
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