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ProteomicsmARC1 knockdown protects liver from diet-induced NASH in mouse
Human genetic studies have identified several MARC1 variants as protective against non-alcoholic fatty liver diseases (NAFLD). The MARC1 variants are associated with reduced lipid profiles, liver enzymes, and liver-related mortality. However, the role of mitochondrial amidoxime reducing component 1 ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-28 | MSV000091820 | MassIVE
TranscriptomicsM-NM-2-Cryptoxanthin suppresses inflammatory gene expression in diet-induced nonalcoholic steatohepatitis in mice
To evaluate the effect of M-NM-2-cryptoxanthin on diet-induced NASH, we fed a high-cholesterol and high-fat diet (CL diet) with or without 0.003% M-NM-2-cryptoxanthin to C56BL/6J mice for 12 weeks. After feeding, M-NM-2-cryptoxanthin attenuated fat accumulation, increases in Kupffer and activated st...
ORGANISM(S): Mus musculus 
2014-05-28 | E-GEOD-51432 | biostudies-arrayexpress
ProteomicsMass Spectrometric Profiling of hepatic GSTM3 - co-immunoprecipitate in Cholesterol-induced Steatohepatic Apoe knockout Mice
Glutathione S-transferase Mu 3 (GSTM3) is a cytosolic detoxification isoform of the glutathione S-transferase family, implicated in cellular redox homeostasis and protection against lipid peroxidation–derived reactive products. Emerging evidence suggests that GSTM3 functions beyond xenobiotic metabo...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-20 | PXD074038 | Pride
Apoe null mice Cholesterol-induced steatohepatitis Liver Glutathione-s-transferase mu 3 Orbitrap Co-immunoprecipitation 
TranscriptomicsInhibiting Monoacylglycerol Acyltransferase 1 Ameliorates Hepatic Metabolic Abnormalities, but not Inflammation and Injury in Mice
Abnormalities in hepatic lipid metabolism are believed to play a critical role in the etiology of nonalcoholic steatohepatitis (NASH). Monoacylglycerol acyltransferase (MGAT) enzymes convert monoacylglycerol to diacylglycerol, which is the penultimate step in one pathway for triacylglycerol (TAG) sy...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-60349 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of livers and liver tumors from mice fed high-fat diet and high fructose-glucose solution for 52 weeks
The lack of a preclinical model of nonalcoholic steatohepatitis (NASH) and hepatocellular cancer (HCC) that recapitulates human disease is a major barrier to therapeutic development. We report a high fat-high sugar diet-induced NASH and HCC in a stable isogenic 129S1/SvImJ crossed with C57Bl/6J mice...
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-67679 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of livers from mice fed high-fat diet and high fructose-glucose solution for 8 weeks
The lack of a preclinical model of nonalcoholic steatohepatitis (NASH) and hepatocellular cancer (HCC) that recapitulates human disease is a major barrier to therapeutic development. We report a high fat-high sugar diet-induced NASH and HCC in a stable isogenic 129S1/SvImJ crossed with C57Bl/6J mice...
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-67678 | biostudies-arrayexpress
GenomicsCholesterol-induced M4-like Macrophages in Non-alcoholic Steatohepatitis recruit Neutrophils and induce NETosis
Cholesterol-induced M4-like Macrophages in Non-alcoholic Steatohepatitis recruit Neutrophils and induce NETosis
PRJNA672312 | ENA
TranscriptomicsA preclinical mouse model of nonalcoholic steatohepatitis and hepatocellular cancer that mimics human disease
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-67680 | biostudies-arrayexpress
Genomicsdietary cholesterol-induced NASH-HCC
Dietary cholesterol promotes steatohepatitis-related hepatocellular carcinoma by inducing aberrant genomic expression and mutations
PRJEB22176 | ENA
UnknownEfficacy of Dietary Lipid Control in Healing High-Fat and High-Cholesterol Diet-Induced Fibrotic Steatohepatitis in Rats.
Not available
S-EPMC4699821 | biostudies-literature
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