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MetabolomicsHypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239
Background: Elevated choline kinase alpha (ChoK) levels are observed in most solid tumors, including glioblastomas (GBM), and ChoK inhibitors have demonstrated limited efficacy in GBM models. Given that hypoxia is associated with resistance to GBM therapy, we hypothesized that tumor hypoxia c...
2024-06-18 | MTBLS6212 | MetaboLights
TranscriptomicsAberrant choline metabolism in epithelial ovarian cancer: relevance of choline kinase activity and expression
Detection of the abnormal phosphatidylcholine (PtdCho) metabolism in EOC by analysis of magnetic resonance profile (MRS), showed a significant increase of PCho content in EOC cells as compared with non tumoral counterparts associated with activation of choline kinase (ChoK), the enzyme responsible f...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-39943 | biostudies-arrayexpress
MetabolomicsDissection of two routes to naïve pluripotency using different kinase inhibitors
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...
2021-02-10 | MTBLS301 | MetaboLights
TranscriptomicsIntegrated analysis of the transcriptome-lipidome reveals the interactions of inositol-choline and SNF1 in controlling lipid biosynthesis
Characterize the transcriptional response to inositol-choline and snf1 We used microarrays to capture the global responses of inositol-choline concentration and snf deletion in Carbon and Nitrogen limited growth
ORGANISM(S): Saccharomyces cerevisiae 
2012-08-29 | E-GEOD-32418 | biostudies-arrayexpress
MetabolomicsThe ULK3 kinase is a key determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...
2022-11-14 | MTBLS5155 | MetaboLights
TranscriptomicsInterstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism.
Nonalcoholic fatty liver disease (NAFLD) is a major health problem and a leading cause of chronic liver disease in the United States and developed countries. In humans, genetic factors greatly influence individual susceptibility to NAFLD. The goals of this study were to compare the magnitude of inte...
ORGANISM(S): Mus musculus 
2014-10-16 | E-GEOD-62362 | biostudies-arrayexpress
TranscriptomicsGene expression data for two xenograft models representing luminal-like and basal-like breast cancer
Choline (reference 1) and glucose (reference 2) was studied using HR MAS MR spectroscopy data and 105 and 38 gene transcripts were selected respectively from the microarray data to study differences between two xenograft models. Reference 1: Moestue SA et al, Distinct choline metabolic profiles are ...
ORGANISM(S): Homo sapiens 
2010-12-08 | E-GEOD-25915 | biostudies-arrayexpress
TranscriptomicsComparative transcriptional analysis of Desulfovibrio alaskensis G20, a choline utilization regulator and LysX
Expression data for Desulfovibrio alaskensis strain G20 and mutants in regulator proteins grown on lactate sulfate media and then pelleted and transferred to another media when they reached stationary phase. The Choline mutant was transferred to lacte/sulfate minimal media and choline/sulfate minima...
ORGANISM(S): Desulfovibrio alaskensis G20 
2013-08-03 | E-GEOD-49528 | biostudies-arrayexpress
TranscriptomicsEffects of maternal choline intake on placental gene expression
To explore the influence of maternal choline intake on placental gene expression, we employed whole genome microarray expression profiling to identify genes that were differentially expressed in placental tissues obtained from women consuming two different doses (480 vs. 930 mg/d) of choline throug...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-39290 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression between sams-1(RNAi) and sams-1(RNAi) animals rescued by choline
Gene expression was compared from adult C. elegans after RNAi Triplicate control RNAi (Empty vector), control RNAi, choline treated, sams-1(RNAi) and sams-1(RNAi) choline treated animals were grown to young adulthood and RNA was extracted
ORGANISM(S): Caenorhabditis elegans 
2015-08-27 | E-GEOD-70693 | biostudies-arrayexpress
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