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Primary micromass cultures derived from 11.5 day old mouse embryo limb buds were cultured for 15 days in differentiating conditions (beta-glycerophosphate and ascorbic acid). Total RNA from differentiating chondrocytes was isolated every three days i.e. days 3,6,9,12 and 15 and hybridized to MOE430A...
ORGANISM(S): Mus musculus 
Next Generation Sequencing Facilitates Quantitative Analysis of undamage chondrocyte and damage chondrocyte whole Transcriptomes
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063537 | Pride
Background: Glucocorticoids (GCs) are widely used anti-inflammatory drugs. While useful in clinical practice, patients taking GCs often suffer from skeletal side effects including growth retardation and decreased bone quality in adults. On a physiological level, GCs have been implicated in the regul...
ORGANISM(S): Mus musculus 
Saul-Wilson syndrome (SWS) is a rare skeletal dysplasia often presents with features such as a distinct facial phenotype, cataracts, short stature, clubfoot deformities, and microcephaly. We have previously identified that the causative mutation in SWS is a heterozygous, dominant variant (p.G516R) i...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036151 | Pride
Background: Results obtained from our previous study using a label-free quantitation (LF) proteomic approach in which dynamic range compression was used to profile lower abundance proteins, demonstrated few proteins that were differentially abundant within the synovial fluid (SF) when comparing Auto...
ORGANISM(S): Homo sapiens (Human) 
2018-05-03 | PXD008321 | Pride
TRIM15 drives chondrocyte senescence and osteoarthritis progression
mRNA expression profiles of engineered chondrocyte sheets
The gene expression profiling among normal chondrocyte, osteoarthritis chondrocyte and chondrosarcoma
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