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Metabolomics1H NMR metabolite monitoring during the differentiation of human induced pluripotent stem cells provides new insights into the molecular events that regulate embryonic chondrogenesis
The integration of cell metabolism with signalling pathways, transcription factor networks and epigenetic mediators is critical in coordinating molecular and cellular events during embryogenesis. Induced pluripotent stem cells (IPSCs) are an established model for embryogenesis, germ layer specificat...
2023-05-24 | MTBLS4854 | MetaboLights
TranscriptomicsChondrogenesis in ATDC5 cells
SAGE analysis of early chondrogenesis in ATDC5 cells induced by BMP4 Keywords: time-course
ORGANISM(S): Mus musculus 
2003-09-10 | E-GEOD-652 | biostudies-arrayexpress
ModelsPatel2023 - miRNA-199a/b-5p regionation of chondrogenesis - enchanced
From a previous microarray study we developed a small chondrogenesis model. We performed qPCR and measured how knockdown of miR-199a-5p or miR-199b-5p could modulate chondrogenesis. Several experiments were used to determine the parameters of this model. We utilised parameter scan and manual sliding...
2023-06-06 | MODEL2305010001 | BioModels
TranscriptomicsThe protein kinase MLTK Is a key regulator for chondrogenesis.
Sox9 acts together with Sox5 or Sox6 as a master regulator for chondrocyte differentiation; however, how these transcription factors functionally interact and collaborate to regulate chondrogenesis remains unclear. Here we show that the protein kinase MLTK plays an essential role in the onset of cho...
ORGANISM(S): Xenopus laevis 
2012-09-04 | E-GEOD-33767 | biostudies-arrayexpress
TranscriptomicsGlobal comparative transcriptome analysis of cartilage formation in vivo
We set out to characterize the gene expression changes which take place during chondrogenesis in the developing mouse limb. RNA derived from pre-condensed mesenchyme, mesenchymal condensations, and cartilage anlagen representing the earliest stages of tibial and fibular development was analysed by ...
ORGANISM(S): Mus musculus 
2012-02-10 | E-GEOD-35669 | biostudies-arrayexpress
TranscriptomicsThe temporal transcriptomic signature of cartilage formation
To study chondrogenesis, we used a chicken limb bud model: We used RNA sequencing, and examined the differences between gene expression patterns during cartilage formation in micromass cultures of embryonic limb bud-derived progenitors. We sequenced in triplicate at Day 0,1,2,3,4,6,10,15 and also fr...
ORGANISM(S): Gallus gallus 
2023-03-28 | E-MTAB-12770 | biostudies-arrayexpress
TranscriptomicsEffects of dynamic compressive loading on MSC chondrogenesis
Long-term dynamic compression enhanced the mechanical properties of MSC-seeded constructs only when loading was initiated after 21 days of chondrogenic differentiation. This study examined the molecular differences of chondrogenic MSCs compared to undifferentiated MSCs (TGF-beta vs no TGF-beta) and...
ORGANISM(S): Bos taurus 
2010-11-01 | E-GEOD-18879 | biostudies-arrayexpress
TranscriptomicsThe immediate early gene product EGR1 and Polycomb Group proteins interact in epigenetic programming during chondrogenesis
Chondrogenic differentiation was induced in ATDC5 cells in the absence (RNAi) or presence of EGR1 (Early Growth Response Protein 1); RNA samples were collected at t=0, 2, 4.5, 8,16, 24, 72 hrs.
ORGANISM(S): Mus musculus 
2013-05-07 | E-MTAB-1464 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MSC isolated from human bone marrow aspirates differentiated to chondrocytes with BMP2 or TGFbeta-3, vs undifferentiated MSC sampled at multiple time points
Human mesenchymal stem cells (MSC) display a high potential for the development of novel treatment strategies for cartilage repair. However, the pathways involved in their differentiation to functional and non hypertrophic chondrocytes remain largely unknown, despite the work on embryologic developm...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-10315 | biostudies-arrayexpress
GenomicsCharacterisation of epigenomic changes during chondrogenesis
Characterisation of epigenomic changes during chondrogenesis
PRJNA529809 | ENA
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