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GenomicsCellular generation of 5-Hydroxymethylcytosine by redox-active chemicals via an unprecedent non-enzymatic mechanism
We proposed that besides TET family dioxygenase oxidizing 5mC to 5hmC, there is a non-enzyme pathway which is due to hydroxyl radica l(OH) or OH-like species also involvement in demethylation of 5mC forming 5hmC. This pathway includes classical fenton reagents such as H2O2 and Fe2+, and more importa...
ORGANISM(S): Homo sapiens 
2013-12-05 | E-GEOD-44457 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of murine T lymphopoiesis
Here we describe microRNA profiling of a single differentiation pathway from the stem cell through to terminally differentated mature cells. Populations corresponding to distinct stages in T lymphocyte development, from the hematopoietic stem cell-enriched Lin-Sca+Kit+ population through to mature C...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-30581 | biostudies-arrayexpress
UnknownIdentification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations.
Not available
S-EPMC4681596 | biostudies-literature
TranscriptomicsTranscriptional hallmarks of heterogeneous neural stem cell niches of the subventricular zone.
Throughout postnatal life in mammals, neural stem cells (NSCs) are located in the subventricular zone (SVZ) of the lateral ventricles. The greatest diversity of neuronal and glial lineages they generate occurs during early postnatal life in a region-specific manner. In order to evaluate potential he...
ORGANISM(S): Mus musculus 
2015-04-07 | E-GEOD-60905 | biostudies-arrayexpress
UnknownResidual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury.
Not available
S-EPMC12860639 | biostudies-literature
UnknownIn vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer.
Not available
S-EPMC6048166 | biostudies-literature
TranscriptomicsMEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma (SCC)
Genomic analyses of SCC have yet to yield significant strategies against pathway activation to improve treatment. Platinum-based chemotherapy remains the mainstay of treatment for SCC of different histotypes either as a single agent or alongside other chemotherapeutic drugs or radiotherapy; however,...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-66549 | biostudies-arrayexpress
GenomicsAscorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals.
DNA demethylation occurs in multiple cellular processes but its regulation is poorly understood. Here we report that a vital nutrient factor ascorbic acid (AA), or vitamin C (Vc), induces DNA demethylation in mammalian cells. The levels of active 5mC oxidation products, 5-formylcytosine and 5-carbox...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-43262 | biostudies-arrayexpress
MetabolomicsNeuroactive metabolites and bile acids are altered in extremely premature infants with brain injury

The gut microbiome has been associated with pathological neurophysiological evolvement in extremely premature infants suffering from brain injury. The exact underlying mechanism and its associated metabolic signatures in infants are not fully understood. To decipher metab...

2023-12-30 | MTBLS7560 | MetaboLights
UnknownFunctional annotation of rare gene aberration drivers of pancreatic cancer.
Not available
S-EPMC4737758 | biostudies-literature
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